Scholarly Publication
Permanent URI for this collection
Browse
Recent Submissions
Now showing 1 - 5 of 88
- ItemAntioxidant and α-Glucosidase Inhibitory Activities of Phenolic Compounds Isolated from the Aerial Parts of Ampelocissus africanus(Natural Product Research Group, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Benin, Nigeria., 2021) 1. Lukman Mustapha, Ezekiel Garba, Umar U. Pateh, Bilqis A. Lawal, Bolatito E. Olanipekun, Florence Tarfa, Augustine A. AhmaduAmpelocissus africanus is an important medicinal plant with diverse ethnomedicinal uses. The purpose of this study was to investigate the antioxidant and α-glucosidase inhibitory activities of phenolic compounds isolated from the aerial parts of Ampelocissus africanus.Two known compounds were isolated using a combination ofcolumn and thin layer chromatography. The structures were elucidated usingUV and NMR spectroscopy. The antioxidant activity of the compounds was evaluated using 2,21-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, while the antidiabetic potential was investigated using the α-glucosidase inhibition assay. Ascorbic acid and acarbose were used as standard and data obtained were expressed as mean ± SEM.The IC50 of the two compounds were calculated using a suitable regression analysis and graph pad prism software 6.0 using t-test.Compounds 1 and 2 were isolated as a yellow solids and identified as methyl gallate and quercetin, respectively. Result of the antioxidant assay using ABTS revealed that compound 1 gave a percentage inhibition of 98.22±0.79, while compound 2 gave 99.04±0.39% inhibition. The DPPH assay revealed inhibition at 59.38±3.23% and 63.45±2.56% for compounds I and 2, respectively. The values for DPPH assay were significantly different at p value <0.05 when compared to ascorbic acid. Compound 2 exhibited α-glucosidase inhibitory activity (IC50 4.02±0.37 μg/mL) though lower than acarbose (IC50 0.98± 0.57 μg/mL). Compound 1 however, showed weak α-glucosidase inhibitory activity with IC50>100μg/mL. These results might justify the ethnomedicinal uses of this plant in ameliorating metabolic disorder such as diabetes.
- ItemAnti-Diabetic Efficacy and Phytochemical Screening of Methanolic Leaf Extract of Pawpaw (Carica papaya) Grown in North Central Nigeria(Turkish Chemical Society, 2017) Ayorinde Victor Ogundele, Kabir Opeyemi Otun, Abdulfatai Ajiboye, Bolatito E. Olanipekun and Rasheed Bolaji Ibrahim,Carica papaya leaf samples (Green) were freshly harvested and dried for six consecutive days. The leaves were extracted with methanol; the resulting extracts were screened for the phytochemical constituents using a standard procedure. Phytochemical screening revealed the presence of bioactive compounds such as tannins, saponins, terpenoids, glycosides, and alkaloids. The in vitro anti-diabetic potential of the plant was also determined so as to justify the traditional usage of the plant in treating diabetes. The result of the present study confirmed that the methanolic extract of C. papaya leaves possess significant anti-diabetic activity in vitro, this shows that the leaves has the potential for the development of drugs in combating diabetes.
- ItemCarbonated Sandcrete-Nanographene Oxide Mortar: Investigating Morphology, Phase Formation, and CO2 Sequestration for Enhance Durability(Faculty of Engineering, University of Benin, Benin City, Edo State, Nigeria, 2024-12-30) 1) Abdullahi, M., Odigure, J.O., Yabagi, I.A., Azeez, S.O.The escalating trend in carbon dioxide emissions is unequivocally linked to global warming and climate change phenomena. This study investigated the morphological development and phase formation of carbonated sandcrete nanographene oxide (S-nGO) composite mortar for CO2 sequestration and durability under ambient conditions (30±2 °C; 50% RH) after 28 days. A comprehensive characterization methodology incorporating X-ray Diffractometer (XRD), X-ray Fluorescence (XRF), Thermogravimetry Analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), EnergyDispersed Spectroscopy (EDS), and Scanning Electron Microscopy (SEM) was used to establish correlations between microstructural changes, degree of porosity, CO2 sequestration, and carbonate concentration. Incorporating nGO during the carbonation transformation in cement-based composites substantially alters the sandcrete matrix's hydration kinetics and associated hydrates, exerting a profound influence on the hydration mechanism. Unlike the control without nanographene oxide, the SEM of S-nGO matrix composites showed a dense microstructure characterized by a foil-like morphology of calcium silicate hydrate (C-S-H) phase containing more carbon, calcium, oxygen, and silicon. The 0.05% S-nGO composite mixture resulted in the highest carbon dioxide sequestration potential, with a carbonate concentration of 0.0406 kg/m3, whereas that of the 0% nanographene oxide control sample was approximately 0.0128 kg/m3 at 30 °C. The findings demonstrated that early-age carbonation (1–28 days) could enhance the durability of the sandcrete–nanographene oxide composite by refining the microstructure and reducing the porosity, thereby improving the material’s overall properties and carbon sequestration potential.
- ItemSynthesis, FT-IR Spectroscopic Studies and in vitro FRAP Assay of some Chalcone Derivatives and their Metal Complexes(ACADEMIC STAFF UNION OF UNIVERSITIES, 2022) Bale, Adebayo Tajudeen; Daramola, Kehinde Dele; Osunniran, Wahab AdesinaA variety of substituted chalcones, namely, 3”-aminochalcone, 2”,4”-dichlorochalcone, 2”-methoxychalcone, 4”-methoxychalcone and 2”-hydroxychalcone have been synthesized by Claisen-Schmidt condensation and characterised by melting point and FT-IR spectroscopic technique. The tin(II), cadmium(II) and copper(II)) complexes of the 2”-hydroxychalcone (4E2HC) with the formula [M(L)2] were subsequently prepared. The 2”-hydroxychalcone and its metal complexes were evaluated for in vitro radical scavenging activity by carrying out ferric reducing antioxidant power (FRAP) assay. In almost all cases, the metal complexes exhibited higher activities than the ligand (chalcone). Notable activity (11.63 µM) was observed for the cadmium complex of the 4-ethoxy-2”-hydroxychalcone at 10 µg/mL. Limited structure–activity relationship (SAR) was established by considering the effect of different groups attached to the aryl rings and the metal centers on varying antioxidant activity. The enhanced activity may be due to the presence of electron-rich metals and electron-releasing ethoxy (-OC2H5) and hydroxy (–OH) groups. The confirmed bioactive compounds from this study can be used as effective template in medicinal chemistry for drug discovery.
- ItemSynthesis and Biological Study of Substituted 2”-Hydoxy, 2”,4”- dichloro Chalcones and Their Co(II), Cu(II) and Ni(II) Complexes for Their Antioxidant and Antimicrobial Potentials(Sami Publishing Company, 2022-02-26) Bale, Adebayo Tajudeen; Fasina, Tolulope Mojisola; Shaibu, Rafiu Olarewaju2-methoxy-2”-hydroxychalcone (2M2HC) and 4-methoxy-2”,4”-dichlorochalcone (4M24DC) and their metal complexes were synthesized, characterized, and confirmed by melting point, FT-IR, UV-Visible, 1H-NMR, EIMS, and AAS spectroscopic techniques. The elemental analysis was done and found following the calculated values. Metal(II) complexes, [M(L1-2)2], [where M = Ni(II), Cu(II), Co(II); L=2-methoxy-2”-hydroxychalcone (2M2HC) and 4-methoxy-2”,4”-dichlorochalcone (4M24DC)] were subsequently prepared. The biological evaluation of the synthesized chalcone derivatives and their metal complexes was done. They were screened for antioxidant and antimicrobial activities. Overall, the ligands (chalcones) and metal complexes demonstrated good to moderate antioxidant and antimicrobial activities.