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- ItemSAFETY EVALUATION OF SOME READY-TO-USE HERBAL CONCOCTIONS SOLD WITHIN ILORIN METROPOLIS(NSUK Journal of Science & Technology,, 2020) Zakariyah, R. F.; Odebisi-Omokanye, M. B.; Saliu, B. K.; Abdulrauf, L. B; Jimoh, F. A; Adebiyi, O. ASafety and quality of indigenous herbal concoctions in Nigeria is of public health concern as the consumption is on the increase. Hence, this study was conducted to evaluate microbial and heavy metals contaminants in selected ready –to- use herbal concoctions within Ilorin metropolis. The heterotrophic microbial counts using pour plate method were assessed and the contaminations of selected heavy metals were analyzed using Atomic Absorption spectrophotometer. The viable plate count for bacteria and fungi ranged between 2.0 ×104 - 10.5 ×105 CFU/ml and 2.0 ×104- 8.3×105 respectively. Bacteria and fungi isolated include Pseudomonas aeruginosa, Micrococcus luteus, Citrobacter freundii, Staphylococcus aureus, Klebsiellia pneumoniae, Corynebacterium kutscheri, Aeromonas hydrophilia, Staphylococcus epidermis, S. cerevisae, Gliocladium sp., Penicillum sp., A. alternata, Aspergillus niger, C. albicans, R. stolonifer, Geotrichum sp and A. flavus respectively. Pb and Cu level concentrations were found to be in the range of 0.1-0.3mg/L and 0.01- 074 mg/L respectively. The concentration of Pb and Cu were generally high and above the safe limits set by WHO/FAO while Cd was not detected in any of the samples. Generally, the consumers of these herbal products are unwittingly exposed to heavy metal poisoning and microbial contaminants. It is suggested that regulatory bodies should intensify efforts to minimize human exposure risk.
- ItemBiosurfactant Production and Characterization by Bacillus altitudinis Strain LCDB-BP3 Isolated from Pesticide-Contaminated Soil in Kwara State, Nigeria(Jewel Journal of Scientific Research (JJSR). Federal University of Kashere-Nigeria, 2024) Abdulsalam Z. B.; Ajao, A. T.; Aborisade, W. T.; Jimoh, F. A.Microbial biosurfactants have gained attention as promising alternatives for bioremediation, particularly for pesticide-contaminated soils, due to their biodegradability and non-toxic nature. These biosurfactants also hold potential for various industrial applications, including food, petroleum, and fertilizer industries, and may serve therapeutic roles as adjuvants. However, there remains a need to produce biosurfactants using indigenous bacterial isolates to address environmental pollution sustainably. In this study, biosurfactant was produced using Bacillus altitudinis strain LCDB-BP3, identified as a Lambda Cyhalothrin-Degrading Bacterium (LCDB- BP3) in a previous research. The biosurfactant-producing ability of the isolate was confirmed by oil displacement (14.32 cm), emulsification activity (70%), and beta-hemolytic activity on blood agar. Stability tests revealed the biosurfactant's resilience across a wide range of temperatures (up to 105°C), pH (3–13), and salinity (3–7%), making it suitable for diverse environmental conditions. Thin-layer chromatography (TLC) and Fourier-transform infrared (FTIR) spectroscopy further confirmed the presence of functional groups such as O-H, N-H, ester carbonyl, and C-H, supporting the lipopeptide nature of the biosurfactant. These findings highlight the potential of the biosurfactant produced by Bacillus altitudinis strain LCDB-BP3 for use in the bioremediation of pesticide-contaminated soils and offer a greener alternative to chemical agents in industrial settings.
- ItemAntibacterial Activities of Methanol and Ethanol Extracts of Moringa oleifera (Lam) Leaves(Jewel Journal of Scientific Research , Federal University of Kashere-Nigeria, 2024) Akanbi-Gada, M. A.,; Amubieya O. F.,; Abubakar, F.A.,; Ajiboye, A. T.; Olorukooba, H. O.,; Jimoh, F. A.; Olabamiji, S. T,; Yahaya, Z. O.; Adenekan, A.Moringa oleifera is known for its therapeutic potential, particularly in treating bacterial infections. This study aimed to determine the Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentration (MBC) of Moringa oleifera extracts (ethanol and methanol) on two bacterial strains: Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive). The extracts were tested at concentrations of 200, 150, 100, 50, and 25 mg/ml. Phytochemical analysis was also conducted. Results showed that Moringa extracts exhibited significant antibacterial activity, with the methanol extract showing an MIC and MBC of 200 mg/ml, and the ethanol extract showing an MIC and MBC of 150 mg/ml. The zones of inhibition were 19 mm (E. coli) and 18 mm (S. aureus) for methanol extract, and 18 mm (E. coli) and 17 mm (S. aureus) for ethanol extract. These results were similar to those of Ciprofloxacin (a standard antibiotic), indicating that Moringa extracts have strong antimicrobial properties. The study suggests that Moringa oleifera could be used as an alternative or adjunct to conventional antibiotics. Future studies should explore the synergistic effects of combining Moringa extracts with existing antibiotics to enhance their effectiveness and combat antibiotic resistance.
- ItemBACTERIOLOGICAL EVALUATION AND PHYSICOCHEMICAL COMPLIANCE OF PACKAGED WATER SOLD IN ILORIN, NIGERIA(FUDMA Journal of Sciences (FJS), 2025) Fausat Abimbola Jimoh; Abdullahi Taiwo Ajao; Wakili Tope Aborisade; Zainab Biola Abdulsalam; Matthew Olatunji KolawoleThis study evaluated the quality of sachet and bottled water sold in Ilorin, Nigeria. Water samples were procured from selling points, and their physicochemical and bacteriological quality was assessed using standard methods. The results showed that the respective physicochemical parameters for sachet and bottle waters: temperature (26.6 °C and 23.9 °C), electrical conductivity (142.0 μs/cm and 111.0 μs/cm), total dissolved solids (68.5 mg/L and 58.0 mg/L), pH (7.5 and 7.3), and salinity (0.05 and BDL) of both sachet and bottled water samples respectively were within the permissible range recommended by the World Health Organization (WHO). Bacteriological analysis revealed that total heterotrophic bacterial counts (52.5*Z ± 4.7 and 35.0Z ± 0.9) for sachet and bottled water samples were within WHO limits; however, total coliform counts (51.50*Z ± 2.6 and 33.5Z ± 1.5) exceeded the acceptable range of 0 CFU/mL. Seven bacterial isolates identified were Pseudomonas aeruginosa, Klebsiella spp., Proteus spp., Enterobacter spp., Salmonella spp., Shigella spp. and Bacillus subtilis. The number of bacterial isolates in bottled water was higher, with Klebsiella spp. being the most prevalent. The findings suggest varying degrees of microbiological contamination, indicating that some packaged water samples are not of the highest quality. These results highlight the need for stricter monitoring and quality control measures to ensure the safety of packaged water
- ItemEffect of chitosan-silver nanoparticle composite-treated water on selected biochemical parameters of rats(Pharmacotherapy Group, University of Benin, Benin City, Nigeria., 2025) Raliat Abimbola Aladodo; Abdulhakeem Olarewaju Sulyman; Mutiu Adewunmi Alabi; Rasheed Bolaji Ibrahim; Juwon Samuel Afolayan; Ibrahim Opeyemi Ibrahim; Fausat Abimbola Jimoh; Yusuf Ayodeji Iyanda; Saheed Sabiu; Chidolue Chinenye KingsleyPurpose: To investigate the impact of chitosan-silver nanoparticles (chitosan-AgNP) composite-treated water on some biochemical parameters in the albino rats. Methods: Water samples were pretreated with chitosan-coated silver nanoparticles (chitosan-AgNPs) prior to oral administration in a rodent model. Following a 28-day experimental period, serum biochemical markers associated with hepatic and renal functions and enzymatic activities were quantitatively assessed to evaluate potential physiological and metabolic alterations. Results: Biochemical analysis revealed significant alterations in liver and kidney function markers in rats exposed to contaminated water. Liver alkaline phosphatase (ALP), aspartate aminotransferase (AST), and γ-glytamyl transferase (GGT) activities were significantly decreased (p < 0.05), while serum ALP, AST and GGT levels were significantly elevated (p < 0.05) in the contaminated water group compared to control. Serum urea and creatinine levels were significantly higher in rats exposed to contaminated water (90 ± 0.08 mg/dL and 21.73 ± 4.03 mg/dL, respectively) compared to the control group (43 ± 0.13 mg/dL and 16.37 ± 1.97 mg/dL, respectively; p < 0.05). Conversely, administration of chitosan-AgNP-treated water significantly reduced these elevations, bringing the values closer to control levels. Bacteriological analysis showed a drastic reduction in total coliform and fecal counts from 1.44 × 10⁷ CFU/mL and 7.2 × 10⁶ CFU/mL, respectively, to 0 CFU/mL after 27 days of chitosan-AgNP treatment. Conclusion: The findings suggest that chitosan-AgNP treatment significantly reduces bacterial load in water and positively affects selected biochemical parameters of albino rats, indicating its potential as a water treatment option.