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    Histological Changes and Lipid Profile Analysis in Male Rats Exposed High Fat Diet
    (International Journal of Basic and Clinical Toxicology, 2022-11-19) Ibrahim Munirudeen; Lawal Abubakar Z; Ogunwale Kola A; Falusi Titilope A; Garuba Wasiu O; Popoola Abdulgafar N; Adunmo Godwin.O; Suleiman Ibrahim E; Busari Akeem O; Balogun Musbau O; Nuhu Abdulrasak
    Abstract Background: High Fat Diet (HFD) is associated with development of cardiovascular, metabolic, liver and central nervous system diseases. The study is aimed at evaluating the effects of high fat diets on lipid profile and selected organs in male wistar rats. Methodology: 24 rats were randomly assigned into 4 groups. Group A received Normal Rat Chow diet + Distilled Water (DW), Group B fed 25% HFD + DW, Group C fed with 50% HFD + DW and Group D fed 100% HFD + DW. Animal’s weights were measured pre and post-treatment. Rats were anaesthetized (diethylether) and sacrificed after 12 hours fast. The blood samples taken from the orbital sinus, centrifuged and serum obtained was used for the assay of lipoprotein A, Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). The brain, liver and heart were excised and processed for histology. Results: Result showed the presence of a significant dose dependent increase (p < 0. 0 5) in the body weight, concentrations of TC, TAG, LDL, lipoprotein A and decrease in the concentrations of HDL in HFD groups compared with the control. Histological results from HFD treated rats have showed no histological abnormalities of the liver, brain and heart tissues. Conclusion: Intake of high fat diets in this study altered serum lipid profile with significant weight gain - a risk factors for cardiovascular and metabolic diseases. Keywords: High Fat Diet, Lipid profile, Lipoprotein A, Histological Changes
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    (2025), Volume 11, Issue 1 Niyi et al. 22 https://ejournals.epublishing.ekt.gr/index.php/HealthResJ RESEARCH ARTICLE EFFECTS OF SALBUTAMOL ADMINISTRATION ON THE MORPHOLOGY AND CYTOAR- CHITECTURE OF THE CEREBELLUM AND HIPPOCAMPUS OF ADULT WISTAR RATS
    (Health and Research Journal, 2025-01) Popoola AbdulGafar Niyi; Ibrahim Munirudeen; Ibiyeye Ruqayyah Yetunde; Faniyi Ayodeji Amos; Balogun Musbau Olusesan; Busari Akeem Olayinka; Garba Wasiu Olanrewaju; Ogunwale Kolawole Ayobami; Lawal Abubakar Zubair; Suleiman Ibrahim Eleha; Adunmo Godwin Olawoyin; Nuhu Abdulrazak
    Abstract Background: Salbutamol is the most preferred and widely used drug for treating bronchial asthma and bronchospasm. Its abuse has however been reported amongst users. Most of the side effects reports on salbutamol are clinical based such as headache, tremor, weakness etc. This study, therefore, investigated the sub-acute effect of oral salbutamol on the general morphology of the cerebellum and hippocampus of adult Wistar rats. Method and Material: Twenty adult Male Wistar rats (125 – 224g) were divided into four groups of five rats each. The control (distilled water); the 20mg/kg salbutamol, the 30mg/kg salbutamol, and the 40mg/kg salbutamol groups. Drugs were administered orally for 21 days. The body weight of each animal was monitored throughout the experiment. On day 22, animals were euthanized, brains excised, fixed in 10% buffered formal-saline, cerebelli and hippocampi were identified and processed with Haematoxylin and Eosin staining techniques. Data were analysed by ANOVA at p≤0.05 level of significance using SPSS and results presented as mean ± SEM Results: Results showed that the animals that received 30mg/kg and 40mg/kg salbutamol had significant weight loss. The cerebellum of the 40mg/kg group showed eroded granule cell layer. Hippocampus also revealed pyknotic cells in the pyramidal cell layers at 30mg/kg and 40mg/kg. Conclusions: This study showed that salbutamol at relatively higher doses caused significant weight loss; degeneration of cerebellum granule cells, which might affect motor coordination; and pyknosis of hippocampal pyramidal cells which may affect learning and memory. Keywords: Salbutamol, weight loss, brain, degeneration.
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    Reproductive Hormone Profiles and Infertility Risk in Heat-Exposed Female Kitchen Workers in Ilorin, Nigeria
    (INTERNATIONAL JOURNAL OF RESEARCH AND SCIENTIFIC INNOVATION (IJRSI), 2024-10) Abdul Gafar Niyi Popoola; Munirudeen Ibrahim; Abdulrazak Ayodeji Mustapha; Wasiu Olanrewaju Garuba
    ABSTRACT The kitchen environment is considered as a potential risk area of heat stress and the kitchen workers are likely victims of infertility disorders due to heat stress. Unlike many other causes of infertility in black communities, hormonal factors have been least researched. This study aimed to investigate the effect of heat stress on female reproductive hormones and FBG among female kitchen staff working within the Ilorin metropolis. It was a cross-sectional comparative study. A purposive sampling technique was used to draw 80 participants comprising 40 female kitchen staff and 40 non-kitchen staff (control). Semi-structured questionnaire was used to obtain information while 5mls of blood was collected from each subject through venipuncture to estimate hormones. Hormones were estimated by ELISA technique while data were analysed using SPSS. Data were significant at p≤0.05. Results revealed that FSH (p=0.01) and progesterone (p=0.039) increased significantly while oestrogen (p<0.0001) and FBG (p<0.0001) decreased significantly compared to the control. A significant correlation was seen between marital status and prolactin level (p=0.02). Also, a significant correlation was found between parity and prolactin levels (p=0.01). LH (p=0.003) and FBG (p=0.01) increased significantly while prolactin level decreased significantly (p=0.02) in participants exposed to combined heat sources compared to others, indicating a significant correlation between sources of heat and the hormones and FBG. The length of occupation as a kitchen staff also had a significant association with the oestrogen level (0.003). The drastic increase in FSH and progesterone levels, along with the tremendous decrease in oestrogen and FBG, indicates a potential threat to fertility in female kitchen staff. Keywords: Heat, female kitchen staff, reproductive hormones.
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    Effects of Aqueous Extract of Ficus Exasperata (Sandpaper Leaf) on Haematological and Some Inflammatory Markers in Wistar Rats Induced Hypertension
    (Al-Hikmah Journal of Health Sciences (AJOHS), 2023-11) Wasiu Olanrewaju Garuba; Gbadebo Maroof Oyeniyi; Ibrahim Munirudeen; Mustapha Abdulrazaq; Akeem Olayinka Busari; Kolawole Tajudeen Ogunwale; olulope Joseph Ogunniyi; Iqmat Abimbola Abdulsalam
    Abstract Hypertension is a global health concern associated with cardiovascular diseases. Ficus exasperata has gained popularity as an alternative therapy to manage hypertension due to its perceived safety and availability. This study evaluated some haematological and inflammatory markers of Ficus exasperata leaf extract in salt-induced hypertensive Wistar rats. Twenty Male Wistar rats were randomly divided into five groups: control, salt-induced + Nifedipine, salt-induced + Ficus exasperata leaf extract (200 mg/kg), salt-induced + Ficus exasperata leaf extract (400 mg/kg), and Ficus exasperate leaf extract (600 mg/kg). Hematological parameters were analyzed using a Hematological autoanalyzer (SYSMEX 1000), Albumin was analyzed using Bromocresogreen (BCG), and C-reactive protein was analyzed using the ELISA method. Data analysis was performed using SPSS version 25, with statistical significance set at p < 0.05. RBC (Red Blood Cell), PCV (Packed Cell Volume), and Hb (Hemoglobin) significantly increased upon treatment with 200 mg/kg body weight of Ficus exasperata leaf extract + 8% salt compared to control at p<0.05. However, the red cell parameters significantly decreased after administering 400 mg/kg and 600 mg/kg body weight of Ficus exasperata at p < 0.05. Albumin increased after treatment with 200 mg/kg body weight of Ficus exasperata leaf extract + 8% salt and 600 mg/kg body weight of Ficus exasperata leaf extract compared to control at p<0.05 but decreased after administering 400 mg/kg body weight of Ficus exasperata leaf extract + 8% salt compared to control at p < 0.05. There was no significant difference in WBC (White Blood Cell) and CRP (C-reactive protein) among the groups p > 0.05. Conclusively, Ficus exasperata leaf extract, particularly at a dose of 200 mg/kg body weight, holds potential as a natural therapy for mitigating salt-induced hypertension and its associated complications
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    Evaluation of Serum Creatine Kinase and Lactate Dehydrogenase Activities in Hypertensive Patients Attending General Hospital Ilorin, Kwara State, Nigeria
    (2021-12) Busari Akeem Olayinka; Onamadi Temitope Ayobami; Ibrahim Munirudeen; Balogun Morufu Eyitayo; Garba Wasiu Olanrewaju; Ogunwale Kolawole Tajudeen; Adunmo Godwin O.; Ahmad Muhammed Bello; Mohammed Idris Yahaya; Nassar Sulaiman Adebayo; Akinola Franklin Folasele; Popoola Niyi Abdulgafar; Lawal Abubakar Zubair; Oyeniyi Maroof Gbadebo; Eleha Suleiman
    Abstract The main factor contributing to morbidity and mortality is hypertension. Although blood pressure is a complicated feature, studies have shown that the activity of adenosine triphosphate (ATP)-generating enzymes like creatine kinase (CK) and lactate dehydrogenase (LDH) is a major predictor of hypertension. As a result, this study evaluated the activities of CK and LDH activities in hypertensive patients attending the General Hospital Ilorin, Kwara State. One hundred and sixty-one (161) hypertensive patients and thirty-nine (39) normotensive subjects were recruited into a case-control study of 200 participants. Body mass index (BMI) was estimated from each participant's measured weight and height, while the blood pressure was determined from the measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) using conventional mercury sphygmomanometer. A 5 mls sample of blood was taken from each subject, and the extracted serum was analyzed using an enzymatic-kinetic method to quantify the CK and LDH activities. Results showed that hypertensive patients had significantly at p<0.05 higher serum CK and LDH activities in hypertensive compared to apparently healthy normotensives. Thus, this study observed significantly increase CK and LDH activities in hypertensive patients