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- ItemReproductive Hormone Profiles and Infertility Risk in Heat-Exposed Female Kitchen Workers in Ilorin, Nigeria(International Journal of Scientific Research and Innovation, 2024-11-26) Abdul Gafar Niyi Popoola, Munirudeen Ibrahim, Abdulrazak Ayodeji Mustapha, Wasiu Olanrewaju GarubaThe kitchen environment is considered as a potential risk area of heat stress and the kitchen workers are likely victims of infertility disorders due to heat stress. Unlike many other causes of infertility in black communities, hormonal factors have been least researched. This study aimed to investigate the effect of heat stress on female reproductive hormones and FBG among female kitchen staff working within the Ilorin metropolis. It was a cross-sectional comparative study. A purposive sampling technique was used to draw 80 participants comprising 40 female kitchen staff and 40 non-kitchen staff (control). Semi-structured questionnaire was used to obtain information while 5mls of blood was collected from each subject through venipuncture to estimate hormones. Hormones were estimated by ELISA technique while data were analysed using SPSS. Data were significant at p≤0.05. Results revealed that FSH (p=0.01) and progesterone (p=0.039) increased significantly while oestrogen (p<0.0001) and FBG (p<0.0001) decreased significantly compared to the control. A significant correlation was seen between marital status and prolactin level (p=0.02). Also, a significant correlation was found between parity and prolactin levels (p=0.01). LH (p=0.003) and FBG (p=0.01) increased significantly while prolactin level decreased significantly (p=0.02) in participants exposed to combined heat sources compared to others, indicating a significant correlation between sources of heat and the hormones and FBG. The length of occupation as a kitchen staff also had a significant association with the oestrogen level (0.003). The drastic increase in FSH and progesterone levels, along with the tremendous decrease in oestrogen and FBG, indicates a potential threat to fertility in female kitchen staff. Keywords: Heat, female kitchen staff, reproductive hormones.
- ItemThe re‐emergence of diphtheria in Nigeria: Descriptive assessment of the post‐COVID‐19 crisis management(2022) Mustapha Abdulrazaq, Tolulope J. Ogunniyi, Fortune B. Effiong, Roseline D. Dine
- ItemRole of apoptotic protease activating factor-1 in CD4+ depletion during HIV progression(2024-06-21) Wasiu O. Garuba , Adebayo L. Adedeji , Kamoru A. Adedokun, Olubunmi G. Ayelagbe , Idris N. Abdullahi , Ibrahim Munirudeen
- ItemReproductive Hormone Profiles and Infertility Risk in Heat-Exposed Female Kitchen Workers in Ilorin, Nigeria(INTERNATIONAL JOURNAL OF RESEARCH AND SCIENTIFIC INNOVATION (IJRSI), 2024-11-26) Abdul Gafar Niyi Popoola, Munirudeen Ibrahim, Abdulrazak Ayodeji Mustapha, Wasiu Olanrewaju GarubaABSTRACT The kitchen environment is considered as a potential risk area of heat stress and the kitchen workers are likely victims of infertility disorders due to heat stress. Unlike many other causes of infertility in black communities, hormonal factors have been least researched. This study aimed to investigate the effect of heat stress on female reproductive hormones and FBG among female kitchen staff working within the Ilorin metropolis. It was a cross-sectional comparative study. A purposive sampling technique was used to draw 80 participants comprising 40 female kitchen staff and 40 non-kitchen staff (control). Semi-structured questionnaire was used to obtain information while 5mls of blood was collected from each subject through venipuncture to estimate hormones. Hormones were estimated by ELISA technique while data were analysed using SPSS. Data were significant at p≤0.05. Results revealed that FSH (p=0.01) and progesterone (p=0.039) increased significantly while oestrogen (p<0.0001) and FBG (p<0.0001) decreased significantly compared to the control. A significant correlation was seen between marital status and prolactin level (p=0.02). Also, a significant correlation was found between parity and prolactin levels (p=0.01). LH (p=0.003) and FBG (p=0.01) increased significantly while prolactin level decreased significantly (p=0.02) in participants exposed to combined heat sources compared to others, indicating a significant correlation between sources of heat and the hormones and FBG. The length of occupation as a kitchen staff also had a significant association with the oestrogen level (0.003). The drastic increase in FSH and progesterone levels, along with the tremendous decrease in oestrogen and FBG, indicates a potential threat to fertility in female kitchen staff. Keywords: Heat, female kitchen staff, reproductive hormones
- ItemRole of apoptotic protease activating factor-1 in CD4+ depletion during HIV progression(International Journal of Health Sciences, Qassim University Saudi, 2024-06-20) Wasiu O. Garuba , Adebayo L. Adedeji , Kamoru A. Adedokun , Olubunmi G. Ayelagbe , Idris N. Abdullahi , Ibrahim MunirudeenObjective: This study investigates the role of Apoptotic Protease Activating Factor-1 (APAF-1) in CD4+ cell depletion among human immunodeficiency virus (HIV) patients. Materials and Methods: This is a cross-sectional study in which 105 participants were enrolled, including 60 confirmed HIV-positive patients and 45 HIV-negative controls. HIV-positive patients were further divided based on CD4+ cell counts: Group 1 (<200), Group 2 (200–499), and Group 3 (≥500). An enzyme-linked immunoassay was used to measure APAF-1 levels, and CD4+ T-cell counts were enumerated using a Cyflow counter. Independent student’s t-test, Kruskal-Wallis, and Spearman’s correlation were utilized as needed. Results: Results showed significant reductions in lymphocytes, platelets, red blood cells, hemoglobin, albumin, and CD4+ cell values among HIV-infected individuals compared to controls. Conversely, APAF-1 and total protein levels were elevated in HIV-positive patients. Among HIV-positive groups, those with CD4+ cell counts <200 exhibited the highest median serum APAF-1 concentration. However, these differences were not statistically significant when compared with the other seropositive groups with CD4+ cell counts between 200 and 499 (P = 0.6726) and CD4+ cell counts of 500 or greater (P = 0.4325). The control group had the lowest median SAPAF-1 concentration, significantly different from HIV-positive groups. Positive correlations were observed between CD4+ counts and lymphocytes, hemoglobin, and hypoalbuminemia, while negative correlations were found between these parameters and APAF-1 levels. Conclusion: APAF-1 is a host factor that potentially contributes to CD4+ cell depletion. Similarly, APAF-1, serum total protein, and albumin levels were found to be predictive of disease progression and could serve as valuable diagnostic biomarkers in the monitoring of HIV/AIDS. Keywords: Apoptotic protease activating factor-1, CD4+ T cell, cytopenia, human immunodeficiency virus/acquired immune deficiency syndrome, hypoalbumin, progressor