Alpha-amylase Inhibition and Brine Shrimp Lethality Activities of Nine Medicinal Plant Extracts from South-West Nigerian Ethnomedicine
| dc.contributor.author | Ogbole Omonike Oluyemisi, Aliu Latifat Olabimpe, Abiodun Oyindamola Olajumoke and Ajaiyeoba Edith Oriabure | |
| dc.date.accessioned | 2025-03-17T12:07:50Z | |
| dc.date.available | 2025-03-17T12:07:50Z | |
| dc.date.issued | 2016-08-12 | |
| dc.description.abstract | Acanthospermum hispidum, Alchornea laxiflora, Calyptrochilum christyanum, Heliotropicum indicum, Holarrhena floribunda, Ipomoea asarifolia, Nauclea diderrichii, Piper guineense, and Tetracera scandens were extracted into methanol and screened for the availability of alpha-amylase inhibitors. Plant extracts’ toxicity was determined by brine shrimp lethality assay (BSLA). The most active plant, Nauclea diderichii, was fractionated into four solvent systems (n-hexane fractions, ethyl acetate, dichloromethane, and n-butanol) and tested. All the extracts showed varying degrees of alpha-amylase inhibitory activity. N. diderrichii with IC50 = 248.30 ± 0.27 μg.mL–1 had the highest inhibitory activity, while its butanol fraction with IC50 = 137.8 μg.mL– 1 had activity comparable to the standard α-amylase inhibitor acarbose (IC50 = 177.50 ± 0.42 μg.mL–1). LC50 values for BSLA ranged from 11.35 to 1,127.50 μg.mL–1, with T. scandens being the most toxic with 11.35 μg.mL–1 and N. diderrichii the least toxic with 1,127.50 μg.mL–1. | |
| dc.identifier.issn | 1049-6475 | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/4799 | |
| dc.language.iso | en | |
| dc.publisher | Journal of Herbs, Spices & Medicinal Plants | |
| dc.title | Alpha-amylase Inhibition and Brine Shrimp Lethality Activities of Nine Medicinal Plant Extracts from South-West Nigerian Ethnomedicine | |
| dc.type | Article |