Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats
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Date
2021
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J Basic Clin Physiol Pharmacology - de gruyter
Abstract
Objectives: The role of aqueous extract of Adansonia dig
itata was investigated against cadmium chloride-induced
testicular damage in Wistar Rats.
Methods: Thirty (30) male Wistar Rats weighing (150–170)
were divided into six groups (n=5). Group A served as con
trol and received oral administration of phosphate buffer
saline; groupBreceived800mg/kgA.digitataonly;groupC
wereinjectedintraperitoneallywithsingledose2mg/kgb.w
cadmium chloride; group D were injected intraperitoneally
with single dose2 mg/kgb.wcadmiumchlorideandtreated
with 800 mg/kg aqueous extract of A. digitata; groupE
received 300 mg/kg vitamin E only; group F were injected
intraperitoneally with single dose 2 mg/kg b.w cadmium
chloride and treated with 300 mg/kg vitamin E. After
21 days, the animals were sacrificed by cervical dislocation,
thetestes wereexcisedfixedinBouinsfluidsforhistological
analysis and the other homogenized in5%sucrose solution for determination of tissue malondialdehyde (MDA) and
antioxidant enzyme activity, biochemical assay.
Results: The group treated with cadmium chloride plus
A. digitata caused significant decrease in MDA levels with
significant increase (p<0.05) in antioxidant activities and
biochemical enzymes when compared to cadmium chlo
ride only group.
Conclusions: Aqueous extract of A. digitata appears to
have ameliorative effect against cadmium chloride
induced testicular damage. This could be attributed to
the presence of polyphenolic compound
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