Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats
| dc.contributor.author | Olugbemi Tope Olaniyan | |
| dc.date.accessioned | 2025-03-12T13:12:08Z | |
| dc.date.available | 2025-03-12T13:12:08Z | |
| dc.date.issued | 2021 | |
| dc.description | NIL | |
| dc.description.abstract | Objectives: The role of aqueous extract of Adansonia dig itata was investigated against cadmium chloride-induced testicular damage in Wistar Rats. Methods: Thirty (30) male Wistar Rats weighing (150–170) were divided into six groups (n=5). Group A served as con trol and received oral administration of phosphate buffer saline; groupBreceived800mg/kgA.digitataonly;groupC wereinjectedintraperitoneallywithsingledose2mg/kgb.w cadmium chloride; group D were injected intraperitoneally with single dose2 mg/kgb.wcadmiumchlorideandtreated with 800 mg/kg aqueous extract of A. digitata; groupE received 300 mg/kg vitamin E only; group F were injected intraperitoneally with single dose 2 mg/kg b.w cadmium chloride and treated with 300 mg/kg vitamin E. After 21 days, the animals were sacrificed by cervical dislocation, thetestes wereexcisedfixedinBouinsfluidsforhistological analysis and the other homogenized in5%sucrose solution for determination of tissue malondialdehyde (MDA) and antioxidant enzyme activity, biochemical assay. Results: The group treated with cadmium chloride plus A. digitata caused significant decrease in MDA levels with significant increase (p<0.05) in antioxidant activities and biochemical enzymes when compared to cadmium chlo ride only group. Conclusions: Aqueous extract of A. digitata appears to have ameliorative effect against cadmium chloride induced testicular damage. This could be attributed to the presence of polyphenolic compound | |
| dc.description.sponsorship | NIL | |
| dc.identifier.citation | 5 | |
| dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/33705611/ | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/4706 | |
| dc.language.iso | en | |
| dc.publisher | J Basic Clin Physiol Pharmacology - de gruyter | |
| dc.relation.ispartofseries | NIL; NIL | |
| dc.title | Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats | |
| dc.title.alternative | Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats | |
| dc.type | Article |