Coordination Compounds of n-phthaloylglycine and n-phthaloyltyrosine and their antimicrobial activities.
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Date
2012-03-28
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Abstract
Coordination compounds derived from N-phthaloylglycine and N-phthaloyltyrosine were
synthesized. The ligands were formed by 1:2 molar condensation of phthalic anhydride with
tyrosine and glycine respectively. The complexes were formulated as [Zn(PHG)2 (H2O)2]
(OAc)2[1], [Ni(PHG)2 (H2O)2] (OAc)2 [2] and [Cu(PHT)2 ] (OAc)2 [3] characterized by
melting point, conductivity, AAS , IR, Uv-Visible spectroscopies. Both ligands were found
to be bidentate. For complexes [1] and [2] the metal ions coordinate through both oxygen of
OH and C=O in the carboxylic group to give octahedral geometry whereas in the [3] the
coordination of metal ion occurs through both oxygen of phenoxyl and carbonyl group
resulting in tetrahedral geometry. The antimicrobial studies using four test
organisms(P.aerugenosa, E.Coli, S. aureus and C. albicans) revealed that the metal
complexes exhibit higher activity than their respective ligands.
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Adedibu, C. Tella, Stephen O. Oguntoye, Osunniran, W. A. and Rotimi O. Arise (2012). Coordination Compounds of n-phthaloylglycine and n-phthaloyltyrosine and their antimicrobial activities. Elixir Appl. Chem, 45: 7620 – 7623. Published by Elixir International Journal (Photonics). Available online at https://www.elixirpublishers.com/