SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF METAL COMPLEXES OF MIXED LIGANDS : CITRIC ACID AND AMODIAQUINE
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Date
2017-12-02
Journal Title
Journal ISSN
Volume Title
Publisher
Bayero Journal of Pure and Applied Sciences
Abstract
A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been
synthesized and characterised using microanalytical technique, elemental analysis, FT-IR
spectroscopy and magnetic measurement. The results of the analytical and spectroscopic data
revealed that both amodiaquine and citric acid acted as bidentate ligands in their mode of
coordination with the metal ions.The citric acid bound through the carbonyl (C=O) and hydroxyl
groups to the metal ions while, amodiaquine coordinated through the nitrogen atom of the
amine and oxygen donor atom of hydroxyl group; resulted in structures with octahedral geometry.
Percentage composition and magnetic Bohr moment data indicated that all metal complexes were
paramagnetic. Molar conductance measurement indicates that the complexes are non-electrolytes
in nature. The antimicrobial activity of the ligands and their mixed complexes was carried out
against g(+)Pseudomonas aeruginosa, g(+)E. coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus
aureus and g(+)Candida using Muller Hinton diffusion method . The citric acid and amodiaquine
result showed low or moderate value from (0.6-0.8) for all the metal complexes with the exception
of the Cu (II) complex having inhibitory zones ranging from 1-0-1.3, 0.7-0.9 at 200 ppm
respectively. Moreover, the free ligands were found being less active compared with their mixed complexes