ACTIVATION OF PRO-APOPTOTIC CELLS, REACTIVE ASTROGLIOSIS AND HYPERPHOSPHORYLATION OF TAU PROTEIN IN TRIMETHYLTIN-INDUCED HIPPOCAMPAL INJURY IN RATS
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Date
2020
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Association of Anatomical Societies of Africa
Abstract
Neurodegenerative diseases cause neural cells to lose both the functional and sensory abilities as a result
of genetic factors, proteopathies and mitochondrial dysfunction. Neurodegeneration forms the basis of
most neurodegenerative disorders for example Alzheimer’s disease, Huntington’s diseases, and
Parkinson’s diseases. The mechanism that underlines the process of neurodegeneration is not well
understood. Understanding the process and mechanism involved in neurodegeneration might offer a
better therapeutic approach to positively manage cases of neurodegenerative diseases. Therefore, this
study’s target was to create an animal model to study neurodegeneration. Sixteen adult male Wistar rats
were used in the study and divided into two groups. Control (0.2 mL of normal saline (NS)), and
trimethyltin-treated (TMT, 8 mg/kg stat dose only). These animals underwent perfusion with
4% paraformaldehyde, brain excision and analysis of p53 antigen, GFAP and Bielshowsky on these
tissues. The results showed that animals in the control group showed presence of activated p53 antigen,
reactive astrogliosis, neurofibrillary tangles, and amyloid plaques within the cytoplasm of the
hippocampal cells. Cornus Ammonis (CA2) and (CA3) showed more of the trimethylrtin injury
than CA1 and CA4. This study thus revealed that, intra-peritoneal administration of single dose
of 8mg/kg of trimethyltin can offer an attractive disease model to study some neurodegenerative
diseases.
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Citation
9. Okesina, A.A., Ajao, M.S., Buhari, M.O., Afodun, A.M., Okesina, K.B., Usman, R.Y., (aka Ibiyeye R. Y.) & Sulaimon, F.A., (2020): Activation of pro-apoptotic cells, reactive astrogliosis and hyperphosphorylation of tau protein in trimethyltin-induced hippocampal injury in rats. Anatomy Journal of Africa. 9(2);1782-1788,