Faculty of Basic and Medical Science

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Browsing Faculty of Basic and Medical Science by Author "A. Oluwasola"

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    A COMPARATIVE STUDY ON THE EFFECTS OF HONEY AND SOME SELECTED BEVERAGES ON HAEMATOLOGICAL PARAMETERS IN MALE WISTAR RATS
    (Al-Hikmah Journal of Education (AHJE)., 2020-06-21) A. Oluwasola; A.O. Akiode; O.E. Ayoola; A. T. Woleola; Garba Sa’adu
    This study investigated a comparative study of the effects of honey and some selected beverages on haematological parameters in male wistar rats. Twenty five male rats (180-220g) were assigned into 5 groups of 5 animals each, such that the rats in groups I, II, III, IV and V received orally 1mL distilled water, 0.2mg/kg body weight (BW) of honey, 0.2mg/kg BW of vitamin C, 0.3mg/kg body weight (BW) of zobo and 0.2mg/kg BW of cocoa power, respectively. White blood cells (WBC), red blood cells (RBC), neutrophils, eosinophils, pack cell volume (PVC), haemoglobin (Hb) and lymphocytes were measured using standard methods. There were no significant differences (p>0.05) in WBC, lymphocytes, neutrophils and eosinophils for all the treated groups when compared to the control. However, there were significant increase (p<0.05) in RBC, Hb and PVC for honey, zobo and cocoa powder -treated groups when compared to vitamin c-treated group and the control. There were also significant increase (p<0.05) in RBC and Hb for honey and zobo-treated groups when compared to cocoa powder, vitamin c-treated groups and the control. This study showed that honey, zobo and cocoa powder stimulate haematological parameters most especially, RBC, PCV and Hb respectively. It is therefore recommended that honey, zobo and cocoa powder could be taken by people with shortage of RBC, PCV and Hb respectively. In addition, honey and zobo are highly recommended because of their high stimulatory effects on haematological parameters.
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    Melatonin Mitigates Hormonal Toxicity in Cannabis -Treated Female Wistar Rats
    (African Journals Online (AJOL), 2023-05-29) A. Oluwasola; O.E. Ayoola; Garba Saa'du; M.A. Adepoju; S.A. Biliaminu; L.A. OLayaki
    Cannabis which is obtained from the flowering tops, Cannabis is obtained from the flowering tops, leaves and resin of the female plant of Cannabis sativa leaves and resin of the female plant of Cannabis sativa L. (family Cannabidaceae), is the most commonly L. (family Cannabidaceae), is the most commonly abused illicit drugs worldwide. It is also one of the abused illicit drugs worldwide1 with medicinal uses.2 commonly abused substances by women of The active component, Ä9-tetrahydrocannabinol (Ä9- childbearing age. Researchers have shown that THC), has been used for treating migraine headache, Cannabinoids have negative effects on the activity of glaucoma, nausea, and anorexia. However, its gonadotropin releasing hormone (GnRH)-secreting detrimental effects on reproductive system have been neurons by direct and indirect mechanisms. Thus, reported. Marijuana is one of the commonly abused researches are needed to mitigate these side effects of substances by women of childbearing age.3 It has been Cannabis-sativa(CS) because of its recreational reported that about 64-79% of female are cannabis purposes which are increasing rapidly. This study users' nationwide3 which can lead to pregnancy loss.4 investigated the effects of CS on hormonal toxicity and Cannabinoids have also been reported to have negative the ameliorative role of melatoninin female rats. effects on the activity of gonadotropin releasing CS significantly (p<0.05) decreased hormone (GnRH)-secreting neurons by direct and gonadotropin releasing hormone (GnRH), follicle indirect mechanisms.5,6,7 Moreover, it has been shown stimulating hormone (FSH), luteinising hormone (LH), to have direct oestrogenic effect on the uterus 8 leading Oestrogen (E), progesterone and prolactin levels of the to the binding of 3â-estradiol to oestrogen receptors.9 It cannabis-treated female ratsrespectively. However,all also has direct effect on the ovary 1011thus, inhibiting these hormones were significantly (p<0.05) reducedby ovarian prostaglandin synthesis which is involved in co-administration of CS with melatonin to the level follicular rupturing during ovulation.11CBR1 is mostly comparable to the control. expressed in the central nervous system (CNS) where it This study showed the hormonal toxicity mediates the central cannabinoids actions. caused by CS which could be mediated by endocrine Peripherally, its expression has been shown to be disruption in female rats. However, these effects could present in the reproductive tissues.12In addition, CB1 be ameliorated by melatonin. Since the consumption of has been found to also be present in the ovary, uterine CS is increasing globally because of its medical uses endometrium, testis, vas deferens, urinary bladder, and leading to its legalization, therefore, consumption of other peripheral endocrine and neurological tissues. melatonin as supplement may be recommended for its CB2 receptors, in contrast, have a fairly limited users. distribution, being found predominantly in immune cells,14mast cells,15 immune cells (B and natural killer cells.