Vitamin E modulates androgen receptor gene expression to attenuate ovarian dysfunctions in a rat model of dehydroepiandrosterone-induced polycystic ovary

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dc.date.accessioned2025-03-17T12:04:28Z
dc.date.available2025-03-17T12:04:28Z
dc.date.issued2023
dc.descriptionNIL
dc.description.abstractObjective: To investigate the protective effect of vitamin E in dehydroepiandrosterone (DHEA)-induced polycystic ovary in rats. Methods: Premature female Wistar rats were randomly allocated into four groups, with 7 rats in each group. Group栺 received corn oil (vehicle) and served as the control group; group栻 received 0.2 mL of 0.06 mg/g DHEA in corn oil; group栿 received 200 mg/kg vitamin E; group 桇 received DHEA plus vitamin E. All treatments lasted for 15 days, with DHEA administered subcutaneously, while vitamin E and corn oil were administered orally. After the experiment, serum samples and ovaries were harvested for biochemical, immunohistochemical, hormonal, and histological analysis. The ovarian mRNA expression of androgen receptor was analyzed by reverse transcriptase quantitative polymerase chain reaction (qPCR). Results: The antioxidant and metabolic enzyme activity significantly decreased in the DHEA-treated rats compared to the control rats (P<0.05). Administration of vitamin E to DHEA treated rats significantly decreased cytokines and malondialdehyde compared to the DHEA-treated rats. The histological analysis showed reduced atretic and cystic ovaries, increased E-cadherin and Bcl-2 expression, and reduced expression of Bax in the DHEA treated rats co-treated with vitamin E. The mRNA expression of androgen receptor was upregulated in the DHEA-treated rats compared to the control rats. Conclusions: Vitamin E ameliorates the hyperandrogenic effect of DHEA-induced polycystic ovaries via metabolic, antioxidant, and anti-apoptotic pathways.
dc.description.sponsorshipNIL
dc.identifier.citation2
dc.identifier.urihttps://journals.lww.com/apjr/fulltext/2023/12020/vitamin_e_modulates_androgen_receptor_gene.6.aspx
dc.identifier.urihttps://kwasuspace.kwasu.edu.ng/handle/123456789/4789
dc.language.isoen
dc.publisherAsian Pacific Journal of Reproduction - Wolters Kluwer- Medknow.
dc.relation.ispartofseriesNA; NA
dc.titleVitamin E modulates androgen receptor gene expression to attenuate ovarian dysfunctions in a rat model of dehydroepiandrosterone-induced polycystic ovary
dc.title.alternativeVitamin E modulates androgen receptor gene expression
dc.typeArticle
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