Dietary inclusion of locally made sweet potato wine protects against biochemical alterations in high cholesterol fed rats

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dc.contributor.authorEmmanuel O. Ajani, Mutiu A. Alabi, Sunday Awe, Latifat B. Ibrahim, Olajumoke A. Awoyemi and Sekinat A. Balogun
dc.date.accessioned2023-07-14T12:49:02Z
dc.date.available2023-07-14T12:49:02Z
dc.date.issued2020
dc.description.abstractBackground and Objective: Sweet potato (Ipomoea batatas) is the 6th most important food crop and possesses anticancer, antidiabetic and anti-inflammatory properties. This study investigated the effect of sweet potato wine in altered biochemical indices in cholesterol fed rats. Materials and Methods: Wister albino rats weighing between 90-120 g were randomized into 8 groups of 10 rats each fed with fresh sweet potato and sweet potato extract. Group 1 (control) were fed normal rat feed and were given sterile placebo (distilled water). Group 2 (negative control) were fed normal rat feed and 2.5% cholesterol. Group 3 (positive control) were fed normal diet, 2.5% cholesterol and standard red wine (400 mL/70 g). Group 4-7 were the treatment groups as follows: TI (2.5% cholesterol+400 mL/70 g potato wine), T2 (2.5% cholesterol+800 mL/70 g potato wine), T3 (400 mL/70 g potato wine) and T4 (800 mL/70 g potato wine). Group 8 (standard control) were fed normal diet and standard red wine (400 mg/70 g). The wines and the cholesterol were daily administered at 9 am and 4 pm, respectively for 5 weeks and the animal were sacrificed 24 h after the last administration. Results: The sweet potato wine and extract: restores abnormalities in lipid profiles in the cholesterol fed rats, does not have a significant effect on the serum renal function biomarkers and the liver function biomarkers were significantly increased. Conclusion: The study suggests that administration of sweet potato wine would be beneficial in restoring lipid profiles while eliciting liver damage which might not have a significant effect on kidney function.
dc.identifier.citationAjani, E.O., Alabi, M.A., Awe, S., Ibrahim, L.B., Awoyemi, O.A. and Balogun, S.A. (2020). Dietary inclusion of locally made sweet potato wine protects against biochemical alterations in high cholesterol fed rats. Trends in Applied Sciences Research., 15: 168-178. Published by Science Alert, Dubai, UAE. Available online at https://scialert.net/fulltext/?doi=tasr.2020.168.178&org=245. Doi: 10.3923/tasr.2020.168.178.
dc.identifier.urihttps://kwasuspace.kwasu.edu.ng/handle/123456789/268
dc.language.isoen
dc.publisherTrends in Applied Sciences Research
dc.titleDietary inclusion of locally made sweet potato wine protects against biochemical alterations in high cholesterol fed rats
dc.typeArticle
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