Dietary inclusion of locally made sweet potato wine protects against biochemical alterations in high cholesterol fed rats
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Date
2020
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Trends in Applied Sciences Research
Abstract
Background and Objective: Sweet potato (Ipomoea batatas) is the 6th most important food crop and possesses anticancer, antidiabetic and anti-inflammatory properties. This study investigated the effect of sweet potato wine in altered biochemical indices in cholesterol fed rats. Materials and Methods: Wister albino rats weighing between 90-120 g were randomized into 8 groups of 10 rats each fed with fresh sweet potato and sweet potato extract. Group 1 (control) were fed normal rat feed and were given sterile placebo (distilled water). Group 2 (negative control) were fed normal rat feed and 2.5% cholesterol. Group 3 (positive control) were fed normal diet, 2.5% cholesterol and standard red wine (400 mL/70 g). Group 4-7 were the treatment groups as follows: TI (2.5% cholesterol+400 mL/70 g potato wine), T2 (2.5% cholesterol+800 mL/70 g potato wine), T3 (400 mL/70 g potato wine) and T4 (800 mL/70 g potato wine). Group 8 (standard control) were fed normal diet and standard red wine (400 mg/70 g). The wines and the cholesterol were daily administered at 9 am and 4 pm, respectively for 5 weeks and the animal were sacrificed 24 h after the last administration. Results: The sweet potato wine and extract: restores abnormalities in lipid profiles in the cholesterol fed rats, does not have a significant effect on the serum renal function biomarkers and the liver function biomarkers were significantly increased. Conclusion: The study suggests that administration of sweet potato wine would be beneficial in restoring lipid profiles while eliciting liver damage which might not have a significant effect on kidney function.
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Ajani, E.O., Alabi, M.A., Awe, S., Ibrahim, L.B., Awoyemi, O.A. and Balogun, S.A. (2020). Dietary inclusion of locally made sweet potato wine protects against biochemical alterations in high cholesterol fed rats. Trends in Applied Sciences Research., 15: 168-178. Published by Science Alert, Dubai, UAE. Available online at https://scialert.net/fulltext/?doi=tasr.2020.168.178&org=245. Doi: 10.3923/tasr.2020.168.178.