Toxicity studies of extract of African Mistletoe: Agelanthus Dodoneifolius Polh and Wiens in Rats
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Date
2020
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Nigerian Biomedical Science Journal
Abstract
A different diseases such as circulatory and respiratory diseases, malaria, diabetes,
hypertension and sterility. The sub-acute toxicity studies of water extract of Agelathus
dodoneifolius was undertaken to assess its safety and tolerability profile in long term treatment.
Sub-acute toxicity (21-days) studies with Agelathus dodoneifolius were done on rats to determine its
consequences on food and fluid intake, body weight, heamatological, biochemical, and mortality.
Rats treated with the extracts had progressive decrease in food, fluid intake and body weight which
was significantly (P< 0.05) and highly significant (P< 0.01) different from control. The water extract
increased both haematological and liver function indices significantly compare to the control. The
renal function parameters were not significantly different in all the groups. These preliminary
results suggest that water extract of Agelanthus dodoneifolius was likely to be non toxic. However,
increase in liver enzymes will require further histopathological and chronic toxicity evaluation to
confirm its safety.
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