Effect of chitosan-silver nanoparticle composite-treated water on selected biochemical parameters of rats
| dc.contributor.author | Raliat Abimbola Aladodo | |
| dc.contributor.author | Abdulhakeem Olarewaju Sulyman | |
| dc.contributor.author | Mutiu Adewunmi Alabi | |
| dc.contributor.author | Rasheed Bolaji Ibrahim | |
| dc.contributor.author | Juwon Samuel Afolayan | |
| dc.contributor.author | Ibrahim Opeyemi Ibrahim | |
| dc.contributor.author | Fausat Abimbola Jimoh | |
| dc.contributor.author | Yusuf Ayodeji Iyanda | |
| dc.contributor.author | Saheed Sabiu | |
| dc.contributor.author | Chidolue Chinenye Kingsley | |
| dc.date.accessioned | 2025-07-08T12:16:24Z | |
| dc.date.available | 2025-07-08T12:16:24Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Purpose: To investigate the impact of chitosan-silver nanoparticles (chitosan-AgNP) composite-treated water on some biochemical parameters in the albino rats. Methods: Water samples were pretreated with chitosan-coated silver nanoparticles (chitosan-AgNPs) prior to oral administration in a rodent model. Following a 28-day experimental period, serum biochemical markers associated with hepatic and renal functions and enzymatic activities were quantitatively assessed to evaluate potential physiological and metabolic alterations. Results: Biochemical analysis revealed significant alterations in liver and kidney function markers in rats exposed to contaminated water. Liver alkaline phosphatase (ALP), aspartate aminotransferase (AST), and γ-glytamyl transferase (GGT) activities were significantly decreased (p < 0.05), while serum ALP, AST and GGT levels were significantly elevated (p < 0.05) in the contaminated water group compared to control. Serum urea and creatinine levels were significantly higher in rats exposed to contaminated water (90 ± 0.08 mg/dL and 21.73 ± 4.03 mg/dL, respectively) compared to the control group (43 ± 0.13 mg/dL and 16.37 ± 1.97 mg/dL, respectively; p < 0.05). Conversely, administration of chitosan-AgNP-treated water significantly reduced these elevations, bringing the values closer to control levels. Bacteriological analysis showed a drastic reduction in total coliform and fecal counts from 1.44 × 10⁷ CFU/mL and 7.2 × 10⁶ CFU/mL, respectively, to 0 CFU/mL after 27 days of chitosan-AgNP treatment. Conclusion: The findings suggest that chitosan-AgNP treatment significantly reduces bacterial load in water and positively affects selected biochemical parameters of albino rats, indicating its potential as a water treatment option. | |
| dc.description.sponsorship | SELF | |
| dc.identifier.issn | 1596-9827 (electronic) | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/5636 | |
| dc.language.iso | en | |
| dc.publisher | Pharmacotherapy Group, University of Benin, Benin City, Nigeria. | |
| dc.relation.ispartofseries | 24; 4 | |
| dc.title | Effect of chitosan-silver nanoparticle composite-treated water on selected biochemical parameters of rats | |
| dc.type | Article |