Neuroprotective effect of dietary black seed flour on key enzymes linked with neuronal signaling molecules in rats exposed to mixture of environmental metals
| dc.contributor.author | J. K. Akintunde1, A. E. Irondi, E. O. Ajani and T. V. Olayemi | |
| dc.date.accessioned | 2025-01-24T22:53:14Z | |
| dc.date.available | 2025-01-24T22:53:14Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | The study examined the neuroprotective effect of dietary black seed flour (D-BSF) in rats exposed to mixed-metals. Animals were divided into six groups (n58): normal control rats; normal rats treated with 10 and 20% black seed flour (D-BSF), respectively; intoxicated rat; intoxicated rats treated with 10 and 20% D-BSF, respectively for 14 days. Our results revealed that neuronal signaling molecules including acetylcholinesterase (AChE), butrylcholinesterase (BuChE), adenosine deaminase (ADA), monoamine oxidase-A (MAO-A) activities, and malonaldehyde (MDA) levels in cerebral cortex were significantly (p<.05) higher followed by alteration in the activity of econucleotidase using ATP, ADP, and AMP as substrates in rats exposed to mixed metals. Remarkably, D-BSF significantly (p<.05) inhibited the activities of AChE, BuChE, ADA, and MAO-A with corresponding wellness of the neuronal MDA contents. However, inhibition of AChE, BuChE, ADA, MAO-A, ectoenzymes activities suggests possible mechanisms by which D-BSF prevent mixed metal toxicity in cerebral cortex of male rats. | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/3249 | |
| dc.title | Neuroprotective effect of dietary black seed flour on key enzymes linked with neuronal signaling molecules in rats exposed to mixture of environmental metals |