Organ Histopathology of Laying Chickens to Bio Control Methods of Aflatoxin Contamination
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Date
2020
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Sciencedomain International
Abstract
Aflatoxin is toxic and carcinogenic to both crops and livestock. Use of different methods of aflatoxin
mitigation has not been very effective. Information on the biological methods in aflatoxin mitigation
is scanty. Therefore, effect of aflatoxin bio-control method on organ weight and histopathology of
layers were investigated. 700 point-of-lay Bovan Nera layers (LC) were randomly allotted to four
dietary treatments (Aflasafe maize-based diet AMBD, FF+ toxin binder, Aflatoxin-contaminated diet
with toxin binder (ACDTB) and Aflatoxin-contaminated diet without toxin binder (ACDWTB). There
were 5 replicates per treatment and experiment lasted for 14 weeks. Histopathology of liver, kidney,
spleen, bursa of fabricus and ileum were assessed using standard procedures. Data were
analysed using descriptive statistics and ANOVA at α0.05. Bursa histopathology of layers fed
ACDTWB showed lymphoid depletion and hepatocellular necrosis, while those fed AMBD showed
lymphoid proliferation and hepatocellular aggregates. Layers fed ACDTB and ACDWTB showed
severe periportal hepatic degeneration and necrosis, with severe periportal cellular infiltration by
mononuclear cells. This was classified as ranging from moderate to severe congestion of the
parenchyma as observed in the lungs. The submucosal lymphoid population was expanded in the
ileum of layers fed AMBD and those fed FF+toxin binder showed severe villi atrophy. Aflasafe
maize-based diet enhanced integrity of the organ weights and histopathology of layers. The use of
bio control method of aflatoxin mitigation (aflasafe) in poultry diet is recommended.