Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria
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Date
2024-06-08
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National Library of Medicine. Annals of African Medicine | Published by Wolters Kluwer - Medknow
Abstract
Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)-infected subjects is critical
for malaria control. Aims and Objectives: This study aims to investigate the nutritional status and innate immune response of Pf-infected
subjects in Lagos, Nigeria. Materials and Methods: A total of 1183 patients with a history of fever or axillary temperature ≥37°C were
screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center
for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z-score is <−2 in the participants aged <20 years. Serum levels of
tumor necrosis factor‑alpha (TNF‑α), interleukin‑1β (IL‑1β), and IL‑12 were determined by capture ELISA while hematological parameters
were measured using an automated hematology system. Results: A total of 384 volunteers were positive for Pf, of which 114 were <20 years
with a median age of 10 years. Overall malaria prevalence was 20.89%. The malnutrition rate was 89.5%; 24 (21.05%) were stunted, 30
(26.32%) were underweight, and 48 (42.11%) were wasted. Pro‑inflammatory cytokine responses were not affected by the type of malaria.
TNF‑α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05). Conclusion: Together, it could be deduced
that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.
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Citation
. al. 2024)“Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria”. Annals of Africa Medicine.1;23(3):379-384