Mn (II), Co (II), Ni (II), and Cu (II) Complexes of Amino Acid derived Schiff base Ligand: Synthesis, Characterization and in-vitro Antibacterial Investigations
Loading...
Date
2021-01-23
Journal Title
Journal ISSN
Volume Title
Publisher
Chemical Society of Ethiopia
Abstract
Four complexes of Mn(II), Co(II), Ni(II) and Cu(II) with Schiff base ligand (H3L) derived from 2-
amino-3-methylbutanoic acid and acetylacetonate were synthesized. All complexes were characterized by
elemental analysis, Fourier-transform infrared spectroscopy and electronic spectroscopy. The results confirmed
the coordination of the ligand to metals in tridentate fashion via the hydroxyl oxygen, the azomethine nitrogen and
the enolic acetylacetonate oxygen. Antimicrobial activities were established for all complexes, free ligand and
ciprofloxacin for comparison. Both the ligand and its metal complexes were active against Gram-positive and
negative bacterial strains. The Cu(II) complex, showed highest antibacterial activity among the complexes
screened. Other complexes displayed considerable antibacterial activity. Octahedral geometry was proposed for
the metal(II) complexes with the Schiff base
Description
Keywords
Citation
Abdullahi O. Rajee, Halimah F. Babamale, Amudat Lawal, Abdulbasit A. Aliyu, Osunniran, W. A., Ayinla, O. Sheriff, Misitura Lawal and Joshua A. Obaleye (2021). Mn (II), Co (II), Ni (II), and Cu (II) Complexes of Amino Acid derived Schiff base Ligand: Synthesis, Characterization and in-vitro Antibacterial Investigations. Bull. Chem. Soc. Ethiop. 35(1), 97-106. Published by Chemical Society of Ethiopia. Available online at https://dx.doi.org/10.4314/bcse.v35i1.8