Synthesis, FT-IR Spectroscopic Studies and in vitro FRAP Assay of some Chalcone Derivatives and their Metal Complexes
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Date
2022
Journal Title
Journal ISSN
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Publisher
ASUU
Abstract
A variety of substituted chalcones, namely, 3”-aminochalcone, 2”,4”-
dichlorochalcone, 2”-methoxychalcone, 4”-methoxychalcone and 2”-
hydroxychalcone have been synthesized by Claisen-Schmidt condensation
and characterised by melting point and FT-IR spectroscopic technique. The
tin(II), cadmium(II) and copper(II)) complexes of the 2”-hydroxychalcone
(4E2HC) with the formula [M(L)2] were subsequently prepared. The 2”-
hydroxychalcone and its metal complexes were evaluated for in vitro radical
scavenging activity by carrying out ferric reducing antioxidant power
(FRAP) assay. In almost all cases, the metal complexes exhibited higher
activities than the ligand (chalcone). Notable activity (11.63 µM) was
observed for the cadmium complex of the 4-ethoxy-2”-hydroxychalcone at
10 µg/mL. Limited structure–activity relationship (SAR) was established by
considering the effect of different groups attached to the aryl rings and the
metal centers on varying antioxidant activity. The enhanced activity may be
due to the presence of electron-rich metals and electron-releasing ethoxy (-
OC2H5) and hydroxy (–OH) groups. The confirmed bioactive compounds
from this study can be used as effective template in medicinal chemistry for
drug discovery.
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Citation
Adebayo Tajudeen Bale, Kehinde Dele Daramola, Osunniran, W. A. (2022). Synthesis, FT-IR Spectroscopic Studies and in vitro FRAP Assay of some Chalcone Derivatives and their Metal Complexes. ASUU Journal of Science, 9(1 & 2): 1-15 .Available at https://ejournals.asuu.org.ng/journal-view.php?type=3&volume=9&vy=2022