Octahedral Platinum (IV) Complexes of Mixed Piperaquine, Sulfadoxine and Pyrimethamine: Synthesis, Spectroscopy, Antioxidant and Antibacterial

Abstract

Synthesis of coordination compounds of Pt (IV) with mixed piperaquine been carried out by 1:1:1 stochiometry ratio of ligands carried out using solubility evaluation, determination of melting point, elemental analysis, UV FTIR, 1H NMR, 13C NMR, DEPT-135 and XRD spectroscopy. FTIR spectral bidendate ligands with pyrimethamine coordinates to the metal centre through (N H) and (S=O); piperaquine through (N-H) and (C six-coordinate with octahedral geometry. The XRD data obtained established the crystal profile and novelty of the metal complexes synthesized. Antioxidant studies carried out using DPPH with ascorbic acid as standard shows me to be promising antioxidant agents with the IC synthesized metal complexes were evaluated against using agar diffusion technique. The results obtained reveal that synthesized metal complexes showed enhanced antibacterial activities when compared to the parent ligands and compete well with oxytetracyclin, a renowned antibiotic. 1A1g 1 1A1g 1 L1+L2+Pt L1 = Piperaquine; L2 = Sulfadoxin Keywords: Piperaquine, platinum (IV) complex, spectroscopy, X Introduction Piperaquine is an antimalarial, belonging to the quinoline group (bisquinoline) which was used in china as prophylaxis and treatment of malaria. The IUPAC name is 4 propanediyldir-4,1-piperanzindyl) bis (7-chloroquinoline). Its mode of action similar to that of chloroquine, however, it becomes an object of renewed interest in combination therap Chemical Sciences _______________________________________ Association Octahedral platinum (IV) complexes of mixed piperaquine, sulfadoxine and pyrimethamine: synthesis, spectroscopy, antioxidant and antibacterial studies , Osunniran Wahab Adesina1 , Obaleye Joshua Ayoola2 , Badeggi Umar Muhammad Ayinde Monsurat Olabisi1 Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Nigeria Department of Chemistry, University of Ilorin, Ilorin, Nigeria Department of Chemistry, Cape Pennisula University of Technology, Cape Town, South Africa yusuf.ayipo@kwasu.edu.ng Available online at: www.isca.in, www.isca.me February 2019, revised 12th May 2019, accepted 5th July 2019 Synthesis of coordination compounds of Pt (IV) with mixed piperaquine-sulfadoxine and piperaquine been carried out by 1:1:1 stochiometry ratio of ligands to metal ion. Characterization of the synthesized complexes was carried out using solubility evaluation, determination of melting point, elemental analysis, UV-visible spectrophotometry, 135 and XRD spectroscopy. FTIR spectral data suggest that all the ligands behaved as bidendate ligands with pyrimethamine coordinates to the metal centre through (N-H) and (C-Cl); sulfadoxine through (N H) and (C-Cl). The electronic spectra also revealed that the metal center moiety is coordinate with octahedral geometry. The XRD data obtained established the crystal profile and novelty of the metal complexes synthesized. Antioxidant studies carried out using DPPH with ascorbic acid as standard shows me to be promising antioxidant agents with the IC50 values of 543, 1031. In vitro antibacterial screening of the ligands and synthesized metal complexes were evaluated against Escherichia coli, Staphylococcus aureus and Bacteria anthrancitis ng agar diffusion technique. The results obtained reveal that synthesized metal complexes showed enhanced antibacterial activities when compared to the parent ligands and compete well with oxytetracyclin, a renowned antibiotic