α-Glucosidase Inhibitory Isomeric Corniculatolides from the Stems of the Indian Mangrove Plant, Xylocarpus granatum
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Date
2020
Journal Title
Journal ISSN
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Publisher
American Chemical Society (ACS)
Abstract
Three new isomeric corniculatolides (1, 2, and 3) with an unusual caffrane and isocorniculane framework, and five known metabolites were isolated from the chloroform extract of the stems of Xylocarpus granatum. The structures of the new metabolites were deduced as corniculatolide B (1), isocorniculatolide B (2), and corniculatolide C (3) by spectroscopic data analysis and a combination
of chemical transformations and supported by single-crystal X-ray
crystallographic data of 1 and 3. The isolated compounds were evaluated for their in vitro cytotoxicity and α-glucosidase (Saccharomyces cerevisiae) inhibitory potential. Compound 3 possessed α-glucosidase inhibitory activity with an IC50 value of 24.8 μM, whereas these rare macrolides showed no effect on the
mammalian cancer cell lines MIAPaCa-2, DU145, MCF-7, and HTC-116.
Description
1. B.E.O. appreciates TWAS-CSIR for the Postgraduate Fellowship award to pursue a Ph.D in CSIR-IICT, Hyderabad, India.
2. This work was supported by the Science and Engineering Research Board, Government of India, through a grant awarded to M.G.P. [EMR/2015/002319].
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Citation
Bolatito E. Olanipekun, Mangala G. Ponnapalli, Karimulla Shaik, Jagadeesh B. Nanubolu, Vamsi K. Kommalapati, and Anjana D. Tangutur (2020): α-Glucosidase Inhibitory Isomeric Corniculatolides from the Stems of the Indian Mangrove Plant, Xylocarpus granatum. Journal of Natural Products, 83, 20−25. Published by American Chemical Society (ACS). Available online at https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.9b00414. DOI:10.1021/acs.jnatprod.9b00414.