Department Public Health Sciences

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An evaluation of the effect of graphene oxide on Saccharomyces cerevisiae
(African Journal of Microbiology Research, 2018-12-21) Nafisat Omotayo; Onyanobi Abel-Anyebe; Oluwasogo Olalubi; Obaid Ullah; Shahlla Mir; Opeyemi Ojekunle; Adedamola Olatoregun; Judith Anglin; Ayodotun Sodipe
Assessment of Mother’s Knowledge and Attitude towards Malaria Management among Under Five (5) Years Children in Okemesi–Ekiti, Ekiti–West Local Government, Ekiti State
(Malaria Control & Elimination, 2016-04-18) Oluwasogo AO; Henry OS; Abdulrasheed AA; Olawumi TA; Olabisi EY
Background: Malaria remains a major global public health and development challenge especially in tropical Africa. Plasmodium falciparum, the deadliest form of the malaria parasite, is responsible for the vast majority of the mortality and morbidity associated with malaria infection. This study therefore, aims to evaluate the caregiver’s knowledge, attitude and practice regarding malaria and treatment of children below five (5) years in the rural community. Methods: A community-based cross sectional survey was conducted in different households among mothers’ with children below five (5) years of age selected by systematic random sampling. In total, 50 respondents were interviewed in the rural community using a semi-structured, paper-based questionnaire designed to capture information on socio-demographic characteristics, active knowledge, treatment seeking behaviour of caregivers/ parents, types of treatment employed by the care-givers and personal protective measures against Malaria. Results: Most respondents correctly associated malaria with infected female anopheles mosquito bites (99.7%) and reported that they will seek treatment within 24 hours of noticing the first symptoms of malaria. Although the respondents were unaware of the susceptibility of children to malaria parasite, thirty seven percent (37%) preferred to use herbs while (17%) will take children to the clinic/dispensary for treatment. Caregivers also make use of artemisinin based combination therapy (ACT) (7%), analgesics (5%), antibiotics (5%) but majority of the respondents use self-prescribed palliative drug combinations/over-the-counter drugs (40%) in treating malaria. They were also aware of preventive measures against malaria such as insecticide treated bed-nets (28%), but there was low ownership and usage of the bed nets among respondents as only 19% of them have access to bed nets. Other preventive measures include spraying with insecticide (29%), wearing long sleeved clothes (29%), and draining of stagnant water (13%). Conclusion: There was dearth of information percolating to mothers most especially on current trends in management, control and prevention of acute uncomplicated malaria in the endemic rural community. Provision of affordable healthcare facilities by government and improved patronage coupled with sound integration of health information and education policy would enhance and promote change of attitude, behaviour and practice will help in combating malaria in the rural endemic settings.
Community-Based Strategies to Improve Primary Health Care (PHC) Services in Developing Countries. Case Study of Nigeria
(Scient Open Access Journal, 2020-02-06) Oluwasogo A. OLALUBI; Ibrahim Sebutu BELLO
Primary Health Care (PHC) still remains the minimum package of healthcare that should be provided to every individual and community across Nigeria Health System. The aim is to improve relatively the health status of the nation ensuring provision of healthcare services to people in the rural area which is indicated by reduced mortality and morbidity and improved survival rates in such communities. However, the situation of health status in Nigeria has not yet attained the desired level. Data shows that as at 2015, the country recorded 814 maternal deaths / 100,000 live births which put her in the same category with the poorest countries in the world such as Chad, Niger and Somalia among others. Furthermore, Nigeria’s health profile reveals that 2,300 under-five children and 145 women of childbearing age die every single day. Moreover, malaria, pneumonia, diarrhoea and other preventable infectious diseases still remain the major causes of under-five deaths in Nigeria. In view of these problems faced by PHC in the country, there is an urgent need for ‘‘one health’’ approach integrating the principal stakeholders, current Minister of Health, state commissioners for health, all 774 Local Government chairmen as well as the National Postgraduate Medical College of Nigeria (NPMCN) to revisit manpower need of PHCs and secondary healthcare facilities. There is also the need for policies restructure, leadership and running of these PHC institutions. Promoting health and prolonging life requires prompt detection and effective management of common communicable and non-communicable diseases cases which can only be achieved through a robust primary healthcare facility. A national health insurance system that provides cover for the vulnerable special groups, aged, the young adolescents, school children, as well as pregnant mothers is a necessity towards reducing inequality in access to basic primary healthcare. This will reduce dependence on out of pocket spending and improve access to healthcare services.
Community-Based Strategies to Improve Primary Health Care (PHC) Services in Developing Countries. Case Study of Nigeria
(Scient Open Access Journal: Journal of Primary Health Care and General Practice, 2020-02-06) Oluwasogo A. OLALUBI; Ibrahim Sebutu BELLO
Primary Health Care (PHC) remains the minimum package of healthcare that should be provided to every individual and community across Nigeria's Health System. The aim is to improve relatively the health status of the nation by ensuring the provision of healthcare services to people in rural areas which is indicated by reduced mortality and morbidity and improved survival rates in such communities. However, the situation of health status in Nigeria has not yet attained the desired level. Data shows that as of 2015, the country recorded 814 maternal deaths / 100,000 live births which put her in the same category as the poorest countries in the world such as Chad, Niger and Somalia among others. Furthermore, Nigeria’s health profile reveals that 2,300 under-five children and 145 women of childbearing age die every single day. Moreover, malaria, pneumonia, diarrhoea and other preventable infectious diseases remain the major causes of under-five deaths in Nigeria. Given these problems faced by PHC in the country, there is an urgent need for ‘‘one health’’ approach integrating the principal stakeholders, the current Minister of Health, state commissioners for health, all 774 Local Government chairmen as well as the National Postgraduate Medical College of Nigeria (NPMCN) to revisit manpower need of PHCs and secondary healthcare facilities. There is also the need for policies for restructuring, leadership and running of these PHC institutions. Promoting health and prolonging life requires prompt detection and effective management of common communicable and non-communicable diseases cases which can only be achieved through a robust primary healthcare facility. A national health insurance system that provides cover for vulnerable special groups, aged, young adolescents, school children, as well as pregnant mothers is a necessity towards reducing inequality in access to basic primary healthcare. This will reduce dependence on out-of-pocket spending and improve access to healthcare services.
Diversity and Abundance of Anopheles (Diptera: Culicidae) Species Complex in some Selected Settlements in Ogbomoso Local Government Area of Oyo-State, Nigeria
(Malaria Contr Elimination MCE, an open access journal, 2016-06-30) Oluwasogo AO; Adeyemi MA; Gabriel S; Kabir OO; Owolabi AA; Henry OS
Background: It is part of efforts of every passionate government in Africa to reduce, if not eliminate morbidity and mortality due to malaria being transmitted by female anopheles mosquito. Part of this struggle is the malaria indicator survey annually conducted by the Federal Bureau of Statistics (FBS) in Nigeria. It therefore important to communicate community based investigation and communication of entomological data vital for malaria control using appropriate statistical tools. This study generally aims to investigate seasonal abundance of Anopheles mosquito species and their compositions in some selected human settlements. The specific objective is to determine which particular specie of such Anopheles mosquitoes are most abundant and which of the human settlements requires most intervention due to high prevalence of such Anopheles. Methods: Mosquito collection was made once per week indoor between 5:30hr to 7:00hr and 20:00hr to 22:00hr in rooms for twelve months using insecticide spray technique. Adult Mosquitoes from the knock down effect were collected and identified to species and species complex level using keys described by Gillett, Gillies and Coetzee. Two sample test of proportion was adopted to test for significant difference between species occurrence. The Friedman rank sum test was utilized to determine whether or not there exists a statistically detectable difference in abundance of the four species of anopheles mosquitoes in the seven study wards and whether the seven study ward significantly differ in their composition of the four species of anopheles complex. Results: At 5% significance level (α=0.05), the test revealed with p-values 0.0001 and 0.0005 that there is statistically detectable difference among median abundance of the four Anopheles species. An. gambiae s.l. had the highest median (3006) abundance, followed by An. arabiensis (834.5), An. rufipes (608) and An. funestus (471), respectively. However, Akata ward had the largest median composition (812) of the mosquito species followed by Lagbedu ward (786). Alapata ward rank third in terms of median abundance (739.5). Ibapon and Ilogbo wards had approximately the same median Anopheles composition of 714 out of the total of 35,974. Arowomole ward had the least median composition (698). However, most mosquito species (6822) was collected in October and the least (252) in February. Conclusion: Identifying human activities and practices that promote mosquito breeding by communities themselves, identifying and selecting culturally appropriate mosquito control techniques, and the initiation of actions aimed at controlling mosquito abundance are among community directed and self-reliant coping strategies envisaged. Among such includes Long-Lasting Insecticide Treated Bednets, (LLITNs) alongside with Indoor residual spray and most importantly the practice of Larval Source Management (LSM) (Larviciding) in the study areas.
Ebola Outbreaks Public Health Emergencies in Fragile Conflicts Zones and Displaced Populations in Africa
(International Journal of TROPICAL DISEASE & Health, 2017-10-11) Ernest Tambo; Oluwasogo A. Olalubi; Chryseis F. Chengho; Isatta Wurie; Jeannetta K. Jonhson; Marcel Fogang; Jeanne Y. Ngogang
Little is documented on conflict and displacement impact on West Africa Ebola Virus disease (EVD) outbreaks. The paper revisits Ebola outbreaks public health emergencies in fragile conflict zones and displaced populations across Africa. Findings showed that the duration of conflict/war events varied one to forty three years. Notably, Darfur war in Sudan and South Sudan lasted between 18- 23 years, RD Congo and Guinea incessant political and ethnical or mining conflict instability repeatedly ranging between 2-6 years, Liberia and Sierra Leone 5 and 12 years conflict/war events associated Ebola outbreaks were documented following seven and four years of conflicts from 1989-1996 and 1999-2003 prior to a democracy nation era in Liberia respectively. Worldwide, there have been 28,639 cases of Ebola virus disease and 11,316 deaths as at December, 2016 compared to recent Zika virus outbreaks in Latin America. Ebola outbreak public health emergencies advocacy, community social mobilization and engagement, Ebola awareness, effective and culturally dignified communications, social media and mass media risk communication, community literacy and preparedness, emergency response engagement and participation, access and deployment of digital technology applications (Health map) in surveillance, tracking and monitoring and key traditional burial practice behaviours changes were being translated into positive successes and benefits that geared rapid and effective prevention of further spread and containment activities of West Africa Ebola outbreak. Inter-humanitarian organizations, institutions and other stakeholders including government cooperation and coordinated leadership, commitment and investment were laudable in supporting accountability and transparency in the overall objectives of public health emergency preparedness planning, care management systems in Ebola outbreak centres, public awareness, epidemic early detection and rapid response as well as effective immunization programs implementation to outwit Ebola virus. Sierra Leone conflict lasted from 1991-2002, Guinea recorded frequent relentless instability than Liberia with two major conflict periods from 1989-1996 and 1999-2003. For the first time, we established a statistical significant correlation between duration of war/conflict events and Ebola outbreaks onsets in Africa (P<0.05).Unexpectedly; the total fatality rate in Liberia or Sierra Leone only was greater than the previously reported cumulative EVD cases across Africa since 1976. It is crucial to intensify advocacy on conflicts/wars resolutions to disaster risk reduction framework evidence practice implementation of peace building in fostering health and socioeconomic development and growth. Authors call for the urgent need for concerned commitment and engagement of all stakeholders to develop, implement and strengthening local, national, regional and global public health emergencies evidence practice approaches and strategies including national public health disaster emergency situations insurance models and schemes integration is paramount in disaster high risk prone settings and particular in Africa.
Ethical, legal and societal considerations on Zika virus epidemics complications in scaling-up prevention and control strategies
(Philosophy, Ethics, and Humanities in Medicine, 2017) Ernest Tambo; Ghislaine Madjou; Christopher Khayeka-Wandabwa; Oluwasogo A. Olalubi; Chryseis F. Chengho; Emad I.M. Khater
Much of the fear and uncertainty around Zika epidemics stem from potential association between Zika virus (ZIKV) complications on infected pregnant women and risk of their babies being born with microcephaly and other neurological abnormalities. However, much remains unknown about its mode of transmission, diagnosis and long-term pathogenesis. Worries of these unknowns necessitate the need for effective and efficient psychosocial programs and medical-legal strategies to alleviate and mitigate ZIKV related burdens. In this light, local and global efforts in maintaining fundamental health principles of moral, medical and legal decision-making policies, and interventions to preserve and promote individual and collective Human Rights, autonomy, protection of the most vulnerable, equity, dignity, integrity and beneficence that should not be confused and relegated by compassionate humanitarian assistance and support. This paper explores the potential medical and ethical-legal implications of ZIKV epidemics emergency response packages and strategies alongside optimizing reproductive and mental health policies, programs and best practice measures. Further long-term cross-borders operational research is required in elucidating Zika-related population-based epidemiology, ethical-medical and societal implications in guiding evidence-based local and global ZIKV maternal-child health complications related approaches and interventions. Core programs and interventions including future Zika safe and effective vaccines for global Zika immunization program in most vulnerable and affected countries and worldwide should be prioritized.
Evaluation of host humoral antibody production against Plasmodium falciparum recombinant circumsporozoite antigen in Nigerian children
(J Vector Borne Dis, 2012-09) Oluwasogo Adewole Olalubi; Ogunlana Oluseyi Ebenezer; Anumudu Chiaka
Background & objectives: The challenge of malaria and efforts targeted at developing malaria vaccines triggered this study on the reactivity of IgG and its subclasses in the test serum specific to CSP. This work was directed at assessing the influence of age and gender on host humoral antibody against Plasmodium falciparum recombinant circumsporozoite antigen in Nigerian children. Methods: In all, 67 serum samples (>10,000 parasites/μl of blood) collected from malaria-infected children at the University College Hospital, Ibadan during the transmission season were analyzed by ELISA. Results: The mean absorbance values of IgG subclasses reactive against P. falciparum CSP appeared to be age dependent and ranged from 0.01 for IgG4 in younger children to 0.95 for IgG3 in older children. The sixty-seven subjects investigated in this study had significantly higher mean IgG1 and IgG3 than the uninfected controls (p <0.01). This follows the order IgG3 >IgG1>IgG2>IgG4 which confirmed the prevalence of the cytophilic antibodies (IgG1 and IgG3) in 65% of the malaria infected children over the non-cytophilic subclasses (IgG2 and IgG4). Similarly, there was low production of IgG4 and IgG2 levels in 35% of the subjects compared with control. IgG was detected in the serum of North American Subjects (NAS) which served as negative control for CSP-specific IgG subclasses. Although the NAS titre was lower than that of the malaria subjects in Nigeria, its IgG2 was, however, higher (0.16) than that of other subclasses. The mean absorbance values of total serum IgG subclass were higher than those of IgG subclasses specific to P. falciparum circumsporozoite antigen. The mean absorbance values of the total serum IgG subclass follows the order IgG2>IgG1>IgG4>IgG3. Interpretation & conclusion: Age and gender-dependent correlations of results suggest that acquired immunity could play a significant role in protection from malaria. Antibody levels are higher in male than female children of the same age group. Antibody levels also increase with age in both the male and female children.
Evidence decision-making policy practice in emerging pandemics and epidemics threats preparedness and response operations in Africa
(Preprints (www.preprints.org), 2018-04-04) Ernest Tambo; Ghislaine Madjou; Christopher Khayeka−Wandabwa; Pascal DJ Chuisseu; Oluwasogo A Olalubi; Jeanne Y. Ngogang
Quality evidence-based decisions and strategies are critical and valuable tools in strengthening health systems policies, strategic priorities action plans and comprehensive care delivery management. Our finding showed that there is scarcity of local/national and internal effective evidence-based and management strategies for informed decision making based on the disease or health epidemics nature, extend, ecological and geo-location of pandemics and epidemics crises burden and impacts. Evidence-based programs or projects are crucial in evolving pandemics and/or (Ebola, meningitis, Cholera and influenza) epidemics persistent morbidity and mortality/ case fatality reduction or prevention; as well as on poverty and inequity alleviation within the vulnerable population and citizenry over time. This paper assesses implications of evidencebased on health systems surveillance and monitoring systems, preparedness and emergency response gaps and needs in improving care delivery uptake and usefulness, coverage and effectiveness in Africa. Furthermore, the article advocates for quality, access to and uptake of knowledge-based policy-decision making and practice improvements in building efficient and standardized surveillance, preparedness and response approaches. Also, in enriching data sharing and inclusiveness through understanding the links between poverty, poor health and inequited related emerging infectious diseases epidemics in Africa. Leveraging on cumulative lessons learnt experiences and innovations in integrating participatory knowledge-based policies and approaches is paramount in fostering vulnerable population awareness and engagement, skills empowerment collaborative productivity and sustainable healthy solutions and measures. Strengthening new partnerships, alliances, and networks requires collaborative and quality evidence policy decisions, appropriate and reliable monitoring and evaluation systems approaches and strategies in improving local preparedness and emergency response capabilities against future emerging infectious diseases epidemics and fast-tracking poverty alleviation knowledge-based livelihoods and health solutions for impact. Furthermore, integrated, participative partnerships and collaborative responsibilities, cost effective and reliable evidence health financing and budget allocation, and targeted capacity development aiming at reducing and averting the burden of poverty related emerging threats and epidemics preparedness and response programs in African countries.
Fostering prevention and care delivery services capability on HIV pandemic and Ebola outbreak symbiosis in Africa
(J Infect Dev Ctries, 2016) Ernest Tambo; Clarence S Yah; Chidiebere E Ugwu; Oluwasogo A Olalubi; Isatta Wurie; Jeannetta K Jonhson; Jeanne Y Ngogang
Human immunodeficiency virus (HIV) and the re-emerging Ebola virus disease (EVD) are closely intertwined and remain a persistent public health threat and global challenge. Their origin and rapid transmission and spread have similar boundaries and share overlapping impact characteristics, including related symptoms and other interactions. The controversies and global threat of these viruses require rapid response policy and evidence-based implementation findings. The constraints and dual burden inflicted by Ebola and HIV infections are highly characterized by similar socio-demographics, socio-economic and political factors. EVD has similar effects and burdens to HIV infection. This study seeks to understand EVD in the context of HIV epidemic despite the challenges in developing an effective vaccine against HIV and EVD. Our findings show that early understanding, prevention and treatment of these diseases a global health threat mainly in Africa is important and valuable. The lessons learned so far from HIV and Ebola epidemics are crucial in health programming and execution of rapid response interventions and continued vigilance against EVD before it become another worldwide health menace. Therefore, the current regional West Africa EVD requires strengthening healthcare systems and building preparedness and response capacity. Importantly, appropriate community participation, health education and resilience coupled with deployment of effective novel diagnostic approaches in early warning and surveillance of threats and emerging diseases. Therefore, there is an urgent need to develop novel key strategies are crucial in curbing the constant viral resurgence, persistence transmission dynamics and spread, as well in accelerating Ebola vaccines regimen (immunization) development and national implementation plans in achieving sustained control, and eventual elimination.
Gender Variation on the Perception of Climate Change Impact on Human Health in Moba Local Government Area of Ekiti State, Nigeria
(http://www.sciencepublishinggroup.com/j/jher, 2018) Biola Badmos; Henry Sawyerr; Gabriel Salako; Atinuke Oyewumi; Adeolu Adedotun; Oluwasogo Olalubi; Olabisi Badmos
This study investigated the influence of gender (sex) on the view of people towards the impact climate change on human health in south-west Nigeria. Data were collected by means of semi-structured questionnaire from impartial sampled males and females in Moba Local Government Area of Ekiti state, Nigeria. Using descriptive statistics and chi-square test, the collected data were analysed for (i) gender variation on the respondent’s perception about climate change, (ii) gender variation in the perception of the respondents as regards the impact of climate change on human health, and (iii) association between sex type and perception on the impact of climate change on human health (malaria, disability, displacement, flooding, and cholera). Males and females showed comparable knowledge about climate change and its impact on human health, but males were slightly knowledgeable. In some aspect, gender showed significant association (p ≤ 0.05) with respondent’s view on the impact of climate change on human health. Females showed better awareness as regards climate change contributing to malaria, while males are better aware as regards climate change contributing to flooding. Important concern revealed in this study is the low public awareness on the indirect health impact of climate change. Hence, continuous enlightenment of people on the various health impacts of the changing climate is recommended.
Geospatial Modeled Analysis and Laboratory Based Technology for Determination of Malaria Risk and Burden in a Rural Community
(International Journal of TROPICAL DISEASE & Health, 2020) Oluwasogo A. Olalubi; Gabriel Salako; Oluwasegun T. Adetunde; Henry O. Sawyerr; M. Ajao; Ernest Tambo
Introduction: Geographical Information System (GIS) has proven to be very useful for large scale mapping of ecosystems, land use and cover, disease prevalence, risk mapping and forecasting. GIS establish relationship or link between vector borne diseases and associated environmental factors thereby providing explanation for spatial distribution pattern, possible causes of diseases outbreak and implications on the community. Aims and Objectives: Our approach in this study was to define and identify areas and places that are exposed to Malaria risk through proximity analysis and to compare geospatial risk with laboratory diagnosed malaria epidemiology. Methodology: Garmin GPS was used to capture the geographic coordinates of six (6) selected settlements and overlaid with georeferenced and processed satellite images in the study area. GIS modeling was performed on risk factors using weighted overlay technique to produce malaria risk map. A total of One hundred and thirty-five (135) vulnerable individuals were diagnosed for Malaria with light Olympus microscope and rapid diagnostic kit (RDT). Data were entered and analyzed using R-Package for Statistical Computing and Graphics. Results: Proximity to malaria risk follows relatively the order Apodu > Central Malete > Elemere > KWASU Campus > Gbugudu. Apodu being the largest place with proximity to malaria risk, within 500 m radius. The risk index increases as one move away from the center of the settlement. The possible explanation for this high risk could be the presence of pond / lake in Apodu. This is a good breeding site for mosquito couple with dense vegetation as one move away from the centre of the settlements. Unlike Apodu, Gbugudu was at medium risk at 100 m buffer (60%) but the risk index decreases as one move away from the settlement centre. The absence of thick vegetation and presence of numerous open farms and partly cultivated farmlands on the eastern part could have been responsible for reduction in risk index. Dense vegetation and ponds were observed within Apodu, while Central Malete was built up with dense vegetation are possible reasons for the high risk index, while settlements within 1 km radius around KWASU campus recorded lower risk index possibly due to low vegetation. The geospatial malaria risk analysis correlates with the laboratory based test results. RDT kits and light microscopy results showed Apodu having the highest malaria prevalence with 46% and 58.7% followed by Elemere 41% and 30.3% respectively. When calculating prevalence by aggregating results across all communities, Apodu still had the highest malaria prevalence for the whole region. RDT and light microscopy results combined for all communities had Apodu with malaria prevalence of 21.48% and 27.4% followed by Elemere with 11.85% and 12.5% respectively. Gbugudu had the least malaria prevalence within the region with 3.7% and 7.4% respectively. Discussion and Conclusion: Findings of this study showed dense vegetation and ponds within Apodu, Elemere and Central Malete served as good breeding site for mosquitoes and were responsible for the high-risk index at these areas. Settlements within 1 km radius around KWASU campus recorded lower index possibly due to low vegetation. Results from this study indicate that the degree of malaria parasitaemia in the three major settlements correlates directly with the remote sensing data.
Glucose absorption in the intestine of albino rats
(J Basic Clin Physiol Pharmacol DE GRUYTER, 2016-01-30) Olalubi A. Oluwasogo; Owoyele B. Victor; Ayinla M. Tayo; Akintunde J. Kehinde
Background: The ability to absorb substances from the external environment is one of the features that make animals different from inanimate objects. In mammalian species, this quality is mainly the small intestine's role. The process of absorption mainly takes place in the small intestine. This study was carried out to investigate the rate of glucose absorption in the intestine of albino rats and the effect of calcium and ouabain on the rate of glucose absorption. Methods: Albino rats weighing between 200 and 250 g were used for this experiment. Guts were isolated and cut to segments. The test solution was injected into each of the isolated segments, which were then assayed for glucose. Results: The result revealed that the rate of glucose absorption in the intestine of albino rats was found to be 3.02 × 10−1 g/min at the mucosa-to-serosa surface and 3.00 × 10−1 g/min at the serosa-to-mucosa surface, indicating that glucose was absorbed in both surfaces and that the rate of glucose absorption was higher in the mucosa-to-serosa direction than in the opposite direction. The rate of intestinal glucose absorption at different regions of the intestine and the effect of varying concentrations of calcium on the rate of glucose absorption revealed that glucose absorption was highest at the duodenum and lowest at the ileum. Conclusions: Ouabain blocked the rate of absorption of glucose in the intestine of albino rats.
Importance of Community Health Insurance Scheme in the attainment of Universal Health Coverage
(National Association of Community Health Practitioners of Nigeria (NACHPN), 2019) Olalubi A. Oluwasogo
Definition of Some Terminologies. Types of Insurance in Nigeria. General Preambles on Health Care. % Sources of Health Care Financing in Nigeria. Definition and Forms of Health Insurance Scheme. The National Health Insurance Scheme (NHIS) in Nigeria: Community-Based Health Insurance and Universal Health Coverage. Importance of CBHIS in Nigeria.
In vitro testing of the susceptibility of Plasmodium falciparum isolates to amodiaquine and the combinations of amodiaquine with verapamil, chlorpheniramine and promethazine
(International Journal of Biology and Biological Sciences Available online at http://academeresearchjournals.org/journal/ijbbs, 2013-07) Oluwasogo A. Olalubi; Oluseyi E. Ogunlana; Abayomi O. Sijuade; Oyindamola O. Abiodun; Olukunle B. Fagbemi
In vitro assays still remain a vital stage of antimalarial drug development process and resistance monitoring. This study assessed the sensitivity patterns of isolates of Plasmodium falciparum to amodiaquine (AQ) alone or in combination with verapamil (VER), chlorpheniramine (CP) and promethazine (PRO) as resistance reversing compounds. The test involves monitoring the ability of antimalarial drugs to prevent parasite transition from trophozoites to schizont stages over a 24-48 h incubation period in vitro by World Health Organization (WHO) schizont inhibition assay. The MIC of AQ alone ranged from 6.2-500.0 ng/ml while those of its reversing agents ranged from 2.1-500.0 ng/ml. Mean MIC for AQ=120.51±15.10. Based on the cut-off value for AQ in vitro susceptibility, 73% (76/104) of the P. falciparum isolates were sensitive to AQ while 27% (28/104) were resistant. The mean MIC values for AQ + VER, AQ + CP and AQ + PRO were 83.08 ± 9.39, 106.93 ± 13.28 and 111.09 ± 14.82 respectively. Based on the reversal phenomenon, 75% (78/104) of the isolates were classified sensitive to amodiaquine, while 25% (26/104) were classified resistant with verapamil as reversing agent (P<0.05). Furthermore, 85% (88/104) were sensitive to amodiaquine while 15% (16/104) were resistant to chlorpheniramine as reversing agent (P<0.05). In the same vein, 78% (81/104) were sensitive to amodiaquine while 22% (23/104) were resistant to promethazine as reversing agent (P<0.05). The present results demonstrated a high sensitivity pattern to the drug combinations. However, the very low levels of in vitro P. falciparum resistance against chlorpheniramine may demonstrate its pharmacological advantage as a better-reversing agent over others. Subsequent surveillance should, in addition, integrate both in vivo and molecular surveillance to characterize the true nature of P. falciparum isolates in this area.
In-Vivo Evaluation of the Antiplasmodial Effect of Amodiaquine and Amodiaquine-Promethazine Combination in Plasmodium berghei Infected Mice
(International Journal of Health Research, Poracom Academic Publishers. Available at http://www.ijhr.org, 2011-06) Oluwasogo A. Olalubi; Oluseyi E Ogunlana; Olukunle B Fagbemi
Purpose: Antihistamine H1 receptor antagonists like promethazine (PR) are capable of reversing resistance of Plasmodium falciparum to some antimalarials drugs like amodiaquine (AQ). This work was carried out to evaluate the antiplasmodial activity of amodiaquine and amodiaquine-promethazine combination in Plasmodium berghei infected mice. Methods: Groups of mice (112) infected with chloroquine resistant Plasmodium berghei ANKA strain were treated with 10mg/kg amodiaquine alone for three days or 10mg/kg AQ combined with graded doses (10, 20, 30, 40, 50 mg/kg) of PR twice daily over 7 days). Thin blood films were used to assess parasitemia for 60 days. Results: Therapeutic effect of AQ combined with graded doses of PR was dose-dependent with the combination of AQ and the highest concentration of PR (50mg/kg) having the shortest parasite clearance time (PCT) (1.28± 0.49) days and longest recrudescence time (RT) of (17.33±11.86 days) compare to AQ alone. The mean PCT was significantly reduced as doses of PR increased up to 50mg/kg (P<0.01). The survival rates (93.8% and 50%) in the group of animals receiving 50mg/kg of PR plus AQ and AQ alone, respectively were significantly different (P<0.01). Conclusion: Promethazine potentiates the therapeutic effects of amodiaquine against the chloroquine resistant P. berghei infection in male albino mice.
Investigation of Blister Beetle(Lytta vesicatoria) Dermatitis outbreak and containment at Karaoke State University Students' Hostels
(2016) Adeyemi Mufutau AJAO; Oluwasogo A. OLALUBI; Ismaila, Adeniran ADEROLU; Shola. K BABATUNDE; Nimat B. IDRIS; Abdulrasheed Abidemi ADIO; E.B AJAO
The study was undertaken to ascertain the causative agent and diagnosis of the clinical profile of patients that made them susceptible to Blister Beetle Dermatitis, efforts were also devoted to investigate risk factors associated with BBD symptoms in patients. This study also provides entomological and environmental data on occurrence and outbreak of BBD at the student hostels in Kwara State University, Nigeria. Patients with clinical manifestation of dermatitis were studied by questionnaire administration along with close clinical examination of the disease condition. The questionnaire sought information on skin lesions, sleeping locations of the patients and beetle activity. The result of the study revealed 44 patients (30 males and 14 females) reported insect bite, dermatitis at and were treated for BBD at the University Medical Centre. The majority of patients were in the age group 10-25years, (77.3%). Thirty four (77.3%) resides in the hostels of the university while others live outside. The commonest body locations affected was the neck (40.9%) and head and face (27.3%). Majority of the cases were reported in October (83%), September (7.8%) and August (2.4%) which coincided with both rainy period and high prevalence of blister beetles collection at the study area. Mean duration of the symptoms manifestation were 3 to 5 days. Fitting houses with good insect screens, light-proof curtains, yellow light bulb and immediate washing of area of contact of beetle on body with soap and water are parts of the precautionary measures proffered.
Molecular Epidemiology of Mycobacterium tuberculosis among Pulmonary Tuberculosis Patients in Ilorin, Nigeria
(Scientific Research Publishing Inc. Health, https://www.scirp.org/journal/health, 2020-07-22) O. A. Olalubi; P. O. Omosigho; A. O. Sodipe; A. I. Lukman
Background: Tuberculosis (TB) is an infectious disease, and it is a public health concern due to the endemic nature of the disease. Nigeria’s health systems still rely heavily on outdated tuberculosis diagnostic tests, including sputum smear microscopy and chest radiography. This necessitated the urgent need to explore a more reliable, effective method that can rapidly enhance the simultaneous detection of Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance. Aims: We evaluated the prevalence of MTB and rifampicin resistance and the influence of socio-demographic factors. Methods: A longitudinal, descriptive study that employs the Xpert MTB/RIF automated molecular method for rapid detection of rifampicin resistance. Secondary data were collected from the medical record from March 2017 to December 2018. Primary data were collected by direct clinical observations and analysis with a gene expert machine from January 2019 to March 2019. Results: Study populations were 1893 subjects pooled as secondary data at the Gene Expert laboratory, with a mean age of 44.92 years and were categorized based on sex, 1125 (59.4%) males and 768 (40.6%) females respectively. The MTB detected were 117 (15.7%) for males while 76 (9.9%) were positive for females. 948 (84.3%) were negative for males and 692 (90.1%) negative for females. Also, the categories for age were grouped into three but the older age groups (29 - 54) and (55 - 80) were more vulnerable to MTB having a p = 0.506 which is statistically non-significant. only 14 (5.5%) have RIF while 239 (94.5%) do not have RIF resistance strains. Logistic regression analysis of MTB detected showed a significant association (p < 0.05) for sex and a non-significant association (p > 0.05) for age. The prevalence rate for RIF Resistance is 5.53%, there is a statistical difference p = 0.001 between RIF Resistance and MTB in Ilorin. Conclusion: The utilization of validated molecular techniques for MTB strain identification has shown a stronger epidemiological impetus for an improved care management outcome specifically in resource-limited areas.
PERCEPTION AND WILLINGNESS TO THE UPTAKE OF COVID-19 VACCINE AMONG HOUSEHOLD-HEADS IN A RURAL COMMUNITY OF SOUTH-WESTERN NIGERIA
(Afr., J. Infect. Dis., 2023-03-29) ADEWOYE Kayode Rasaq; OLALUBI Oluwasogo; AREMU Shuaib Kayode; ALAO Taiye Adeyanju; EKPO David Sylvanus; IPINNIMO Tope Michael; ADENIYI Makinde Adebayo; IBRAHIM Azeez Oyemomi; SANNI Taofeek Adedayo; ACHEBE Chijioke Cosmas; BAKARE Adewumi; OREWOLE Tesleem Olayinka; ABIOYE Opeyemi Oladipupo; OREWOLE Tesleem Olayinka
Background: The COVID-19 pandemic and its vaccine have been met with varying perceptions that may have both negative and positive effects on the willingness to uptake the COVID-19 vaccine. The study is set to determine the perception and willingness of the household heads to the uptake of COVID-19 vaccine in a rural community in Southwestern, Nigeria. Materials and Methods: A cross-sectional study was carried out among 409 household heads selected through a multistage sampling technique. The instrument of data collection was a semi-structured interviewer-administered questionnaire using the Health Belief model constructs. Data were analyzed with IBM SPSS version 21.0 and Pearson's Chi-square test was used to determine the association between perception and willingness to uptake vaccine. P<0.05 was taken as significant at 95% confidence interval. Results: The majority of the unvaccinated respondents in the study were not willing to take the COVID-19 vaccine (60.1%). There was a poor perception of the susceptibility/severity of unvaccinated respondents to COVID-19 infection and a poor perception of the benefit/barrier to the uptake of the COVID-19 vaccine. Perception of susceptibility and severity of COVID-19 infection were statistically related to the willingness to uptake the COVID-19 vaccine. Conclusion: There should be an increase in awareness campaigns to change the perception of people positively to COVID-19 infection and uptake of the COVID-19 vaccine.
Prevalence and risk factors of Schistosoma haematobium infections among primary school children in Igbokuta Village, Ikorodu North Local Government, Lagos State
(IOSR Journal of Nursing and Health Science (IOSR-JNHS), 2013-11) Olalubi A. Oluwasogo; Olukunle B. Fagbemi
Background: Urinary Schistosomiasis (US) caused by Schistosoma haematobium constitutes a major public health problem in Nigeria. Efforts in this study were devoted to evaluate the current prevalence and associated risk factors on the intensity of disease burden. Methods: A survey was conducted with the use of semi-structured questionnaires to collect sociodemographic and anthropometric data of the pupils. Urine samples were collected from One hundred and two (102) pupils for microscopic analysis for the detection of S.haematobium eggs. Results: Of the 102 children (age ranges between 5-15 years) examined, prevalence of infection was (80/102) 78 % of which (44/102) 43 % were heavy and (36/102) 35 % mild while (22/102) 22 % were negative (p<0.05). The frequency of infection was higher among the female pupils (62/102) 61 % compared to the male counterpart (40/102) 39 % (p<0.05). Striking risk factors that could predispose the pupils to S.haematobium infection follows the order: swimming / drinking contaminated water> washing of clothes in streams > playing / bathing in rivers> unknown > mosquito bites > fresh water snail. No significant difference exists between the risk factors (p>0.05). The mean age, weight, height, waist circumference and hip circumference of the negative individuals (both males and females) were significantly higher than that of their positive counterpart (p<0.05). There was no significant difference in the mean age, height and waist circumference of the heavy and mild infected females compared to their male counterpart (p>0.05). Similarly, there was no significant difference in the mean hip circumference of the heavy and mild infected male and female (p>0.05). Correlation analysis showed that there is significant correlation between infection status and age (r= 0.385, p>0.01), weight (r = 0.404, p>0.01), height (r=0.401, p>0.01), waist (r=0.396, p>0.01), hip circumference (r=0.415, p>0.01) and risk factor (r=-0.231, p>0.05). Risk factor is not significant to age, weight, height, waist, hip circumference and infection status (p>0.05). Conclusion: Prevalence rate obtained in the study was high, an indication that the region is endemic by WHO classification. This calls for an urgent effective urinary schistosomiasis control programme in the zone.

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