Browsing by Author "Hitler Louis"

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    A Review on Classes, Extraction, Purification and Pharmaceutical Importance of Plants Alkaloid
    (Journal of Medicinal and Chemical Sciences, 2019-08-18) Hamzat T. Adejoke; Hitler Louis; Oluwatobi O. Amusan; Gloria Apebende
    playsvital role in the prevention and treatments of diseasessuch as cancer, malaria, pile etc. These natural products which include alkaloid, flavonoid, phenol, saponin and tannin are bioactive compounds in plant and essential in plant metabolic activities. All of these have been tested for their huge medicinal properties and therefore could serve as an alternative medicine in treatment of myriad ailments. Although, through the modern-day technologies, these bioactive compounds have been separated from the plants and synthesized into capsules and tablets for easy administration, usage and storage, there is a need to create awareness on the side-effects associated with excess or abuse of medicinal plants and to encourage rational use of natural resources for sustainability. Thus, this review gives an overview on pharmacological importance of named alkaloids, methods of extraction and purification of alkaloids in plant, laying emphasis on side-effects associated to the abuse of alkaloids or alkaloid derivative drugs.
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    ANTIMICROBIAL STUDY OF SOME TRANSITION METAL COMPLEXES OF RHODANINE AND SALICYLADIMINE
    (Asian Journal of Basic and Applied Science, 2018-09-10) Oluwatobi Omotola Amusan; Hitler Louis; Oluwatomosin F. Oyebanji; Temitope Adejoke Hamzat; Thomas Odey Magu; Aderemi T adeleye
    In this study, complexes of copper and zinc with rhodanine and salicyladimine were examined for their antimicrobial properties against selected bacteria species. The complexes were also characterized using infra-red and ultra-violet spectroscopy for structural elucidation and determination of electronic transitions occurring between the ligands and their complexes. All the complexes showed varied inhibition on the growth of the test organisms at different minimum inhibitory concentrations ranging from 0 – 25 mg/ml. The infra-red spectroscopy showed the presence of different functional groups like O-H stretching vibration at 3441cm-1, C- H bending at 833.28cm-1 and 750.33cm-1, C=C stretching vibration at 2360.95cm-1 in the salicyladimine ligand and N-H stretching vibration at 3448.84cm-1 in the complex formed with copper, whereas Rhodanine shows C=O at 1734cm-1 with copper acetate, 1708.99cm-1 with Zinc nitrate, C-H stretching at 3086.21cm-1, 3074.63cm-1 with copper and 3174.94cm-1 with zinc. The ultraviolet spectroscopy showed absorptions assigned to different geometry. The complex of salicylaldimine showed two bands around 26385 cm-1 and 42016 cm-1 which are assigned to square planar geometry. Rhodanine showed four bands around 48780 cm-1, 33898 cm-1, 39525 cm-1 corresponding to n→π* transition and 26809 cm-1 corresponding to n→σ* transition. Rhodanine complex with zinc nitrate showed two bands around 23925cm-1 and 22411cm-1 assigned to charge transfer. Rhodanine complexed with copper acetate showed two bands around 20283 cm-1 and 24096 cm-1 which are assigned to square planar geometry. From the analysis of variance, there is no significant difference (p-value= 0.05) in the antibacterial activity and the selected pathogen. Based on this study, we recommend that metal complexes should be used to restrict the growth of bacteria in place of Ligands
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    Determination of Cadmium Concentration in Eight Nigerian Food Samples from Some Selected Markets using Atomic Absorption Spectrophotometric Method
    (IJESPR, 2018-08-08) Hamzat Adejoke Temitope; Hitler Louis; A. T Aderemi; Pigweh I. Amos; Oluwatobi Omotola Amussan; Thomas Odey Magu; S. A Lawani
    This study investigates the presence of cadmium in eight Nigerian food samples from Oja Oba, Ojuwoye and Kuto markets in Kwara, Lagos and Ogun State respectively. The food samples were analyzed using atomic absorption spectrometer. The results obtained revealed that cadmium was present in all the food samples that were analyzed at different concentration ranging from 0.001 ppm to 0.007 ppm. The results showed a permissive concentration of cadmium in the food samples as compared to FAO/WHO Expert Committee on food additives (EFSA, 2012) weekly limit of 2.5 μg/kg body weight. Since trace amount of cadmium is expected in almost all food samples due to natural conditions, it is necessary to pay close attention to cadmium contamination in food samples as continuous intake of food containing cadmium is dangerous to health
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    Synthesis and characterization of CaO catalyst obtained from achatina achatina and its application in biodiesel production
    (Journal of Medicinal and Nanomaterials Chemistry, 2019-03-12) Oluwatobi O. Amusan; Hitler Louis; Adejoke T. Hamzat; Oluwatomisin F. Oyebanji; Ayodeji T. Alagbe; Thomas O. Magu
    In this research study, Achatina achatina shells was used as the source of raw material to produce calcium oxide which was used as a catalyst in the production of biodiesel. The main aim of this study was to investigate the effect of varying temperatures on the calcium oxide formed using A. achatina during the calcination process for their possible use as a heterogeneous catalyst in the production of biodiesel. The shells were first grinded and then calcinated at different temperatures ranging from 0 °C to 1000 °C. After calcination, the CaCO3 present in the A. achatina shell was converted to calcium oxide. The obtained calcium oxide was characterized using Fourier transform infrared spectroscopy (FT-IR). The asymmetric stretching of the CO32- (cm-1) absorption was not proportional with the increasing temperature as it was observed over the plane vibrational modes of CO32 (cm-1). Also, the O-H stretching band (cm-1) at 100 °C and 800 °C had similar absorption values. Pearson correlation revealed both negative and positive relationship between the absorption rate and the temperature, disclosed a significant difference at p<0.05. The calcined structure was examined using scanning electron microscope (SEM) with a magnification of 10,000X. A more stabilized, uniform structure, and agglomerate into lumps were observed at 800 °C and 1000 °C. The results showed that, the A. achatina shell is a suitable catalyst in the production of Biodiesel because it is readily available and has no adverse effect on the environment.