Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility

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dc.contributor.authorOlugbemi T. Olaniyan
dc.date.accessioned2025-03-12T12:49:58Z
dc.date.available2025-03-12T12:49:58Z
dc.date.issued2020
dc.descriptionNIL
dc.description.abstractAbstract: Severeacuterespiratorysyndromecoronavirus2 (SARS- CoV-2) that causes COVID-19 infections penetrates body cells by binding to angiotensin-converting enzyme-2 (ACE2) receptors. Evidence shows that SARS-CoV-2 can also affect the urogenital tract. Hence, it should be given serious attention when treating COVID-19-infected male patients of reproductive age group. Other viruses like HIV, mumps, papilloma and Epstein–Barr can induce viral orchitis, germ cell apoptosis, inflammation and germ cell destruction with attending infertility and tumors. The blood-testis barrier (BTB) and blood-epididymis barrier (BEB) are essential physical barricades in the male repro ductive tract located between the blood vessel and semi niferous tubulesinthetestes.Despitethesignificantroleof these barriers in male reproductive function, studies have shown that a wide range of viruses can still penetrate the barriers and induce testicular dysfunctions. Therefore, this mini-review highlights the role of ACE2 receptors in pro moting SARS-CoV-2-induced blood-testis/epididymal bar rier infiltration and testicular dysfunction.
dc.description.sponsorshipNIL
dc.identifier.citation41
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/jbcpp-2020-0156/html?lang=en&srsltid=AfmBOopsXkyMlW4zgmcEdTuTC4sU4YhFzpoYCezdUVA_5d4WEm5PY8Rj
dc.identifier.urihttps://kwasuspace.kwasu.edu.ng/handle/123456789/4634
dc.language.isoen
dc.publisherJ Basic Clin Physiol Pharmacol 2020 - DE GRUYTER
dc.relation.ispartofseriesNIL; NIL
dc.titleTestis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility
dc.title.alternativeTestis and blood-testis barrier in Covid-19 infestation
dc.typeArticle
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