Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
SciTechnol.
Abstract
Sildenafil citrate, a specific phosphodiesterase-5 (PDE-
5) inhibitor drug currently used for the treatment of erectile
dysfunction in men. The present study investigates the effects of
Sildenafil citrate on antioxidant defense systems of testes and
brain tissues of male rats by measuring the GSH, SOD, and CAT
activity. Lipid peroxidation was also estimated by measuring the
MDA levels, a Thiobarbituric Acid Reactive Substrate (TBARS)
as biomarker of oxidative stress. Sildenafil citrate was orally
administered at the different dose levels of 20 mg/kg body weight
per 30 days in four divided doses of 50, 100, 150 and 200 mg/kg
body weight while control rats were given distilled water. The result
revealed that Sildenafil citrate significantly increased MDA levels in
testes. Conversely, the MDA levels in brain tissue was significantly
reduced P<0.05. However, a significant increase in GSH content
of testes and brain was observed. Similarly, superoxide dismutase
(SOD) and catalase (CAT) activities for both tissues increased
significantly (p<0.05) compared to their corresponding control. The
histological examination of the testicular tissues revealed no visible
lesions. Collectively, the results suggest that therapeutic dose of
Sildenafil citrate elicits modulatory roles by stabilizing/boosting
antioxidant defense systems in male rat.
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Citation
Akintunde, J.K., Ajiboye, J.A., Slemuri, D. O, Oyelowo, S.B., Sunday, O.J., Abam, E.O. and Irondi, A.E. (2012) “Sub-Chronic Treatment of Sildenafil citrate (Vigra) on some Enzymatic and Non-enzymatic Antioxidants in Selected Tissues of Male Rat” J.Pharm. Drug Deliv Res,1:1.