Comparison of Solid and Solvent - Based Syntheses, Characterization and Antioxidant Property of Metal Complexes of Sodium Diclofenac
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College of Natural and Applied Sciences, Fountain University, Osogbo, Nigeria
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Abstract
Mechanosynthesis and solvent – based syntheses of transition metals (Ni, Co and Zn) complexes of
Sodium diclofenac has been carried out by 1:1 molar ratio of the ligand to metal salts respectively. The
synthesis of the metal complexes were confirmed by melting point determination, FT-IR (Fourier
Transform Infra-red) and UV-visible spectroscopies. The ligand showed bidentate coordination to the
metal ions through carboxylate moiety. Octahedral geometry was proposed for all the metal complexes.
The antioxidant property of metal complexes was determined using DPPH (1,1-diphenyl-2-
picrylhydrazyl) assay with Ascorbic acid as control. The antioxidant evaluation results revealed that the
synthesized metal complexes are promising antioxidant agents
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Osunniran, W. A., Ayipo, Y. O, Adeyemo, M. A., Bale A. T., Obaleye, J. A. (2020). Comparison of Solid and Solvent - Based Syntheses, Characterization and Antioxidant Property of Metal Complexes of Sodium Diclofenac. Fountain Journal of Natural and Applied Sciences 9(1): 11-18. Published by College of Natural and Applied Sciences, Fountain University, Osogbo, Nigeria. Available online at DOI: 10.53704/fujnas.v9i1.291