Efficient Support Vector Machine Classification of Diffused Large B-Cell Lymphoma and Follicular Lymphoma mRNA Tissue Samples

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dc.contributor.author11. Banjoko A. W.
dc.contributor.authorYahya W. B.
dc.contributor.authorGarba M. K.
dc.contributor.authorOlaniran O. R.
dc.contributor.authorDauda K. A.
dc.contributor.authorOlorede K. O.
dc.date.accessioned2025-05-27T14:34:35Z
dc.date.available2025-05-27T14:34:35Z
dc.date.issued2015
dc.description.abstractIn this study, an efficient Support Vector Machine (SVM) algorithm that incorporates feature selection procedure for efficient identification and selection of gene biomarkers that are predictive of Diffuse Large B–Cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) cancer tumor samples is presented. The data employed were published real life microarray cancer data that contained 7,129 gene expression profiles measured on 77 biological samples that comprised 58 DLBCL and 19 FL tissue samples. The dimension reduction approach of the Welch statistic was employed at the feature selection phase of the SVM algorithm. The cost and kernel parameters of the SVM model were tuned over a 10–fold cross-validation to improve the efficiency of the SVM classifier. The entire sample was randomly partitioned into 95% training and 5% test samples. The SVM classifier was trained using Monte Carlo Cross validation approach with 1000 replications. The performance of this classifier was assessed on the test samples using misclassification error rate (MER) and other performance measures. The results showed that the SVM classifier is quite efficient by yielding very high prediction accuracy of the tumor samples with fewer differentially expressed genes. The selected gene biomarkers in this work can be subjected to further clinical screening for proper determination of their biological relationship with DLBCL and FL tumour sub groups. However, more studies with large samples might be needed in future to validate the results from this work.
dc.identifier.citation11. Banjoko A. W., Yahya W.B., Garba M.K., Olaniran O.R., Dauda K.A., and Olorede K.O. (2015). Efficient Support Vector Machine Classification of Diffused Large B-Cell Lymphoma and Follicular Lymphoma mRNA Tissue Samples. Annals Computer Science Series. Vol. XIII, 69-79. URL: http://anale-informatica.tibiscus.ro/download/lucrari/13-2-08-Banjoko.pdf
dc.identifier.urihttps://kwasuspace.kwasu.edu.ng/handle/123456789/5298
dc.language.isoen
dc.publisherAnnals Computer Science Series
dc.relation.ispartofseriesVol. XIII
dc.titleEfficient Support Vector Machine Classification of Diffused Large B-Cell Lymphoma and Follicular Lymphoma mRNA Tissue Samples
dc.typeArticle
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