Cocos nucifera L. oil alleviates lead acetate induced reproductive toxicity in sexually-matured male Wistar rats
| dc.contributor.author | Olugbemi T. Olaniyan | |
| dc.date.accessioned | 2025-04-07T12:58:53Z | |
| dc.date.available | 2025-04-07T12:58:53Z | |
| dc.date.issued | 2021 | |
| dc.description | NIL | |
| dc.description.abstract | Objectives: Lead primarily affects male reproductive functions via hormonal imbalance and morphological damagetothetesticulartissuewithsignificantalterationin sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investi gating the effect of Cocos nucifera L. oil on lead acetate induced reproductive toxicity in male Wistar rats. Methods: Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III— 6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificedbydiethylether,afterwhichtheserum,testisand epididymis were collected and used for semen analysis, biochemical and histological analysis. Results: The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, whileasignificantreduction(p<0.05)inspermparameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions: Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties. | |
| dc.description.sponsorship | NIL | |
| dc.identifier.citation | 6 | |
| dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/33713589/ | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/4952 | |
| dc.language.iso | en | |
| dc.publisher | J Basic Clin Physiol Pharmacology de gruyter | |
| dc.relation.ispartofseries | NIL; NIL | |
| dc.title | Cocos nucifera L. oil alleviates lead acetate induced reproductive toxicity in sexually-matured male Wistar rats | |
| dc.title.alternative | Cocos nucifera L. oil alleviates lead acetate | |
| dc.type | Article |