Effect of Aqueous Extract of Ocimum gratissimum (Scent Leaf) on Renal Profile of Male Wistar Rats

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dc.contributor.authorBusari Akeem Olayinka
dc.contributor.authorSalau Fatimoh Abimbola
dc.contributor.authorBashir Shefiat
dc.contributor.authorBolaji Moshood
dc.contributor.authorBalogun Morufu Eyitayo
dc.contributor.authorIbrahim Munirudeen
dc.contributor.authorGaruba Wasiu Olanrewaju
dc.contributor.authorPopoola Niyi Abdulgafar
dc.contributor.authorAdunmo Godwin O.
dc.contributor.authorLawal Abubakar Z.
dc.contributor.authorOgunwale Kolawole Tajudeen
dc.contributor.authorAdedokun Kamoru Ademola
dc.contributor.authorOgundiran Simeon Makinde
dc.contributor.authorAhmad Muhammad Bello
dc.contributor.authorMohammed Idris Yahaya
dc.contributor.authorAkinola Franklin Folasele
dc.contributor.authorAdeosun Oyebola Ganiyu
dc.date.accessioned2025-01-28T08:37:55Z
dc.date.available2025-01-28T08:37:55Z
dc.date.issued2021-12
dc.description.abstractAbstract Humans have given the leaves of Ocimum gratissimum (O. gratissimum) a great deal of attention due to their vast medical usefulness, culinary application, and pharmacological effects. As a result, the study evaluated the effect of O. gratissimum on renal profile of male Wistar rats. Ten healthy male Wistar rats were randomized into test and control groups comprising of 5 animals each. The test group received 400mg/Kg O. gratissimum leaf extract whereas the control group was fed with normal rat diet and water. The rats were euthanized through cervical dislocation at the end of the experiment and blood sample was collected through heart puncture for serum assessment renal profile while the kidney was excised for histological examination. The Results showed a non-significant at p>0.05 increase in serum electrolytes and urea while significant at p<0.05 decrease in the mean serum creatinine level was observed in the test group compared to the control group. Also, the histological examination of the kidney tissue revealed a mild lymphocytic infiltration in the test group compared to the control group. Conclusively, the study suggested a dose-dependent toxicological effect of O. gratissimum on renal profile.
dc.identifier.citationBusari, A.O., Salau, F.A., Bashir, S., Bolaji, M., Balogun, M.E., Ibrahim, M., Garuba, W.O., Popoola, N.A., Adunmo, G.O., Lawal, A.Z., Ogunwale, K.T., Adedokun, K.A., Ogundiran, S.M., Ahmad, M.B., Mohammed, I.Y., Akinola, F.F., Adeosun, O.G. (2021). Evaluation of Serum Creatine Kinase and Lactate Dehydrogenase Activities in Hypertensive Patients Attending General Hospital Ilorin, Kwara State, Nigeria, Al-Hikmah Journal of Health Sciences, 1(1), 7-13.
dc.identifier.issn2811-1516
dc.identifier.issn2811-1524
dc.identifier.urihttps://kwasuspace.kwasu.edu.ng/handle/123456789/3403
dc.language.isoen
dc.publisherAl-Hikmah Journal of Health Sciences (AJOHS)
dc.titleEffect of Aqueous Extract of Ocimum gratissimum (Scent Leaf) on Renal Profile of Male Wistar Rats
dc.typeArticle
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