Methanol extracts of Brachystegia eurycoma and Detarium microcarpumseeds flours inhibit some key enzymes linked to the pathology andcomplications of type 2 diabetes in vitro
| dc.contributor.author | Irondi Emmanuel Anyachukwu | |
| dc.contributor.author | Oboh Ganiyu | |
| dc.contributor.author | Akindahunsi Afolabi Akintunde | |
| dc.date.accessioned | 2023-07-17T11:11:52Z | |
| dc.date.available | 2023-07-17T11:11:52Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | The inhibitory effect of methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours on some key enzymes [alpa-amylase, alpha-glucosidase and aldose reductase (AR)] linked to the pathology and complications of type 2 diabetes (T2D); and their antioxidant properties were evaluated. The antioxidant properties evaluated were DPPH• and ABTS•+ scavenging abilities, reducing power, and antioxidant phytochemicals (total phenolics, tannins, total flavonoids and total saponins). Extracts of both flours inhibited alpha-amylase, alpha-glucosidase and AR in a dose-dependent manner. The half-maximal inhibitory concentrations (IC50) of B. eurycoma on alpha-amylase, alpha-glucosidase, AR and lipid peroxidation were lower than those of D. microcarpum, indicating that it had stronger inhibitory potency than D. microcarpum. B. eurycoma also had significantly (P < 0.05)higher DPPH•and ABTS•+scavenging abilities, and reducing power than D. microcarpum. The antioxidant phytochemicals (total phenolics, tannins, total flavonoids and total saponins) were also significantly (P < 0.05) higher in B. eurycoma than D. microcarpum. The inhibitory effect of B. eurycoma and D. microcarpum extracts on alpha-amylase, alpha-glucosidase and AR activities may be attributed to the combined action of their polyphenols and total saponins, and this may be a possible mechanism of action providing support for their use in managing hyperglycemia and the complications of T2D. | |
| dc.identifier.citation | 40. Irondi E.A., Oboh G. and Akindahunsi A.A. (2015). Methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours inhibit some key enzymes linked to the pathology and complications of type 2 diabetes in vitro. Food Science and Human Wellness; 4: 162–168. | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/342 | |
| dc.language.iso | en | |
| dc.publisher | ScienceDirect | |
| dc.title | Methanol extracts of Brachystegia eurycoma and Detarium microcarpumseeds flours inhibit some key enzymes linked to the pathology andcomplications of type 2 diabetes in vitro |