MIXED LIGANDS COMPLEXES OF METRONIDAZOLE: SYNTHESIS AND ANTIBACTERIAL STUDIES

Abstract

The synthesis of some transition metal complexes of metronidazole with oxalic acid have been reported and characterized using conductivity measurement, melting point determination, elemental analysis, infrared and ultraviolet/visible spectroscopic methods. Both ligands were bidentate in their moe of coordination with the metal ions. The antibacterial studies were investigated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Klebsiella pneumonia. Mn(MET)(OXA)Cl2 has the highest inhibition against Klebsiella pneumonia, while Cu(MET)(OXA)Cl2 has the lowest inhibition against Bacillus subtilis.