Synthesis, Characterization, Antibacterial and Toxicological Studies of Heteroleptic Acetylsalicylic Acid and Anthranilic Acid Metal Complexe
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Date
2022-12-16
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10.faculty of sciences and technology of the university of El Oued (Algeria)
Abstract
This present study aims at evauating the antibacterial, analgesic, and toxicological activities
of new metals [Ni(II), Cu(II), Cd(II), and Zn(II)] complexes derived from acetylsalicylic acid
and anthranilic acid via refluxing method in a 1:1:1 stoichiometry ratio. Characterization was
executed using melting point, molar conductance, infrared and ultraviolet-visible
spectroscopies. The antibacterial activities were investigated by the agar well diffusion
method. The toxicological effect of the test compounds in serum and kidney homogenates of
Wister rats was investigated. The screened complexes showed better antibacterial activities
than their free ligands. The result of the analysis indicated that acetylsalicylic acid possessed a
good significant analgesic activity, while toxicological studies confirmed that the complexes
were toxic at the level of administered dosage
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Citation
Mercy O. Bamigboye, Ikechukwu P. Ejidike, Osunniran, W. A., Juliana B. Adetunji, Joshua A. Obaleye, Catherine A. Adenipekun (2023). Synthesis, Characterization, Antibacterial and Toxicological Studies of Heteroleptic Acetylsalicylic Acid and Anthranilic Acid Metal Complexes. J Fundam Appl Sci. 15(1): 62-82. doi:http://dx.doi.org/10.4314/jfas.1261