Synthesis and Characterisation of Some Mixed Artemisinin-Thiamin Chloride and Artemisinin-Pyridoxine- Metal Complexes and Their Antimicrobial Activity Studies

Abstract

Metal complexes of Zn2+, Mn2+, Cu2+ and Fe3+ with mixed Artemisinin-thiamin chloride and Artemisinin-pyridoxine have been synthesized and characterized using infrared, electronic and 1H-NMR spectroscopy, melting point and conductivity measurements. Artemisinin-thiamin chloride complexes coordinate through the hydroxyl and amide groups, while Artemisinin-pyridoxine complexes coordinate through the hydroxyl and cyanide groups, both in bidentate coordination geometry. Antibacterial screening of the complexes against five bacteria species- Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas auriginosa and Proteus mirabilis, was also investigated. The metal complexes were found to have varied degrees of inhibitory effect against the bacteria species under study.