Synthesis and Biological Study of Substituted 2”-Hydoxy, 2”,4”- dichloro Chalcones and Their Co(II), Cu(II) and Ni(II) Complexes for Their Antioxidant and Antimicrobial Potentials

Abstract

2-methoxy-2”-hydroxychalcone (2M2HC) and 4-methoxy-2”,4”-dichlorochalcone (4M24DC) and their metal complexes were synthesized, characterized, and confirmed by melting point, FT-IR, UV-Visible, 1H-NMR, EIMS, and AAS spectroscopic techniques. The elemental analysis was done and found following the calculated values. Metal(II) complexes, [M(L1-2)2], [where M = Ni(II), Cu(II), Co(II); L=2-methoxy-2”-hydroxychalcone (2M2HC) and 4-methoxy-2”,4”-dichlorochalcone (4M24DC)] were subsequently prepared. The biological evaluation of the synthesized chalcone derivatives and their metal complexes was done. They were screened for antioxidant and antimicrobial activities. Overall, the ligands (chalcones) and metal complexes demonstrated good to moderate antioxidant and antimicrobial activities.