INVESTIGATION OF ANTI-PLASMODIUM ACTIVITY OF A COMBINED EXTRACT OF Bryophyllum pinnatum and Aloe barbadensis LEAVES
| dc.contributor.author | Abdulazeez, A. Abubakar., Kolawole, Deboye., Babatunde, K. Shola., Sunday, O. Joseph & Ameen, Nimat. | |
| dc.date.accessioned | 2026-04-21T11:02:22Z | |
| dc.date.available | 2026-04-21T11:02:22Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Anti-malaria drug resistance is a major public health challenge causing a serious setback to the roll back malaria programme in Africa. This study therefore attempted to explore the combinatorial effect of Aloe barbadensis and Bryophyllum pinnatum on malaria parasitemia with the aim of producing an effective anti-malaria preparation. Extracts of both plants were prepared at varying concentrations of 10-1 to 10-9 mg/ml and were administered orally to Plasmodium berghei infected albino mice. The mode of extract administration was both single, using individual extracts and combined, using mixture of both extracts. The infected animals in test group were given the extract at a dose of 0.5ml per day for 3 consecutive days, the negative control animals were administered with placebo while the positive control animals were treated with Lumefantrine/arthemisinin combination. After the third day, thin and thick blood films were made from the blood collected from the tail of the animal and examined for malaria parasites. Pre and post test malaria parasitemia and test and control malaria parasitemia were determined and compared. At all the concentrations of Aloe barbadensis extract administered, no significant variation in malaria parasitemia was observed before and after application of the extract. Similarly, with Bryophyllum pinnatum extract, data obtained also showed no significant reduction in the density of malaria parasite when post-test density was compared with pre-test. A combination of both extracts however revealed a synergistic effect. Post-application results of the extract indicated that at 10-1 and 10-3 mg/ml concentrations, significant reduction in malaria density was recorded when post –treatment malaria density was compared with pre-treatment.(P < 0.05). However none of the extract concentrations was able to clear malaria parasitemia completely in the experimental animal. In conclusion although the combinatorial effect of both plants produced remarkable reduction in malaria parasitemia, no case of complete clearance was recorded | |
| dc.identifier.citation | Abdulazeez, A. Abubakar., et. al., (2014) “Investigation of Anti-plasmodium Activity of a Combine Extract of Bryophyllum pinnatum and Aloe barbadensis Leaves” International Journal of Science and Nature, 5:1, (67-70) (Q2). | |
| dc.identifier.uri | http://www.scienceandnature.org/IJSN_Vol5(1)2014.php | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/6605 | |
| dc.publisher | Science and Nature. | |
| dc.relation.ispartofseries | 5:1, (67-70) | |
| dc.title | INVESTIGATION OF ANTI-PLASMODIUM ACTIVITY OF A COMBINED EXTRACT OF Bryophyllum pinnatum and Aloe barbadensis LEAVES |