Inhibition of 𝛼-Amylase and 𝛼-Glucosidase Activities by 2-Hydroxy-1,4-Naphthoquinone
| dc.contributor.author | Sulyman, O.A., Iyanda, A.Y., Aladodo, A.R., and Balogun, A. | |
| dc.date.accessioned | 2025-02-02T20:57:37Z | |
| dc.date.available | 2025-02-02T20:57:37Z | |
| dc.date.issued | 2024-06 | |
| dc.description.abstract | The purpose of the present study was to investigate the 𝛼-amylase and 𝛼-glucosidase inhibitory potentials of 2-hydroxy-1,4-naphthoquinone (2HNQ). The inhibition of these two carbohydrates metabolizing enzyme was done by varying the concentrations of 2HNQ in the presence of α-amylase, α-glucosidase with starch and p-nitrophenylglucopyranoside (pNPG) respectively as their substrates. The mode of inhibitions of the two enzymes by 2HNQ was determined using double-reciprocal transformation. The result obtained indicated that 2HNQ inhibited 𝛼-glucosidase activity with an IC50 0.260 mg/mL lowered than acarbose (1.530 mg/mL). Meanwhile, a moderate inhibitory potential of 2HNQ against 𝛼-amylase was observed with an IC50 of 1.757 mg/mL compared with acarbose (IC50 of 3.600 mg/mL). Furthermore, 2HNQ amazingly mops up reactive oxygen species. The observed inhibitions of α-amylase and α-glucosidase activity as well as radical scavenging potentials of 2HNQ suggest that it may be a potential target for the management of diabetes mellitus | |
| dc.identifier.uri | https://kwasuspace.kwasu.edu.ng/handle/123456789/3831 | |
| dc.publisher | Physiological Society of Nigeria | |
| dc.title | Inhibition of 𝛼-Amylase and 𝛼-Glucosidase Activities by 2-Hydroxy-1,4-Naphthoquinone |