Browsing by Author "Wasiu Olanrewaju Garuba"

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    Effects of Aqueous Extract of Ficus Exasperata (Sandpaper Leaf) on Haematological and Some Inflammatory Markers in Wistar Rats Induced Hypertension
    (Al-Hikmah Journal of Health Sciences (AJOHS), 2023-11) Wasiu Olanrewaju Garuba; Gbadebo Maroof Oyeniyi; Ibrahim Munirudeen; Mustapha Abdulrazaq; Akeem Olayinka Busari; Kolawole Tajudeen Ogunwale; olulope Joseph Ogunniyi; Iqmat Abimbola Abdulsalam
    Abstract Hypertension is a global health concern associated with cardiovascular diseases. Ficus exasperata has gained popularity as an alternative therapy to manage hypertension due to its perceived safety and availability. This study evaluated some haematological and inflammatory markers of Ficus exasperata leaf extract in salt-induced hypertensive Wistar rats. Twenty Male Wistar rats were randomly divided into five groups: control, salt-induced + Nifedipine, salt-induced + Ficus exasperata leaf extract (200 mg/kg), salt-induced + Ficus exasperata leaf extract (400 mg/kg), and Ficus exasperate leaf extract (600 mg/kg). Hematological parameters were analyzed using a Hematological autoanalyzer (SYSMEX 1000), Albumin was analyzed using Bromocresogreen (BCG), and C-reactive protein was analyzed using the ELISA method. Data analysis was performed using SPSS version 25, with statistical significance set at p < 0.05. RBC (Red Blood Cell), PCV (Packed Cell Volume), and Hb (Hemoglobin) significantly increased upon treatment with 200 mg/kg body weight of Ficus exasperata leaf extract + 8% salt compared to control at p<0.05. However, the red cell parameters significantly decreased after administering 400 mg/kg and 600 mg/kg body weight of Ficus exasperata at p < 0.05. Albumin increased after treatment with 200 mg/kg body weight of Ficus exasperata leaf extract + 8% salt and 600 mg/kg body weight of Ficus exasperata leaf extract compared to control at p<0.05 but decreased after administering 400 mg/kg body weight of Ficus exasperata leaf extract + 8% salt compared to control at p < 0.05. There was no significant difference in WBC (White Blood Cell) and CRP (C-reactive protein) among the groups p > 0.05. Conclusively, Ficus exasperata leaf extract, particularly at a dose of 200 mg/kg body weight, holds potential as a natural therapy for mitigating salt-induced hypertension and its associated complications
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    Reproductive Hormone Profiles and Infertility Risk in Heat-Exposed Female Kitchen Workers in Ilorin, Nigeria
    (INTERNATIONAL JOURNAL OF RESEARCH AND SCIENTIFIC INNOVATION (IJRSI), 2024-10) Abdul Gafar Niyi Popoola; Munirudeen Ibrahim; Abdulrazak Ayodeji Mustapha; Wasiu Olanrewaju Garuba
    ABSTRACT The kitchen environment is considered as a potential risk area of heat stress and the kitchen workers are likely victims of infertility disorders due to heat stress. Unlike many other causes of infertility in black communities, hormonal factors have been least researched. This study aimed to investigate the effect of heat stress on female reproductive hormones and FBG among female kitchen staff working within the Ilorin metropolis. It was a cross-sectional comparative study. A purposive sampling technique was used to draw 80 participants comprising 40 female kitchen staff and 40 non-kitchen staff (control). Semi-structured questionnaire was used to obtain information while 5mls of blood was collected from each subject through venipuncture to estimate hormones. Hormones were estimated by ELISA technique while data were analysed using SPSS. Data were significant at p≤0.05. Results revealed that FSH (p=0.01) and progesterone (p=0.039) increased significantly while oestrogen (p<0.0001) and FBG (p<0.0001) decreased significantly compared to the control. A significant correlation was seen between marital status and prolactin level (p=0.02). Also, a significant correlation was found between parity and prolactin levels (p=0.01). LH (p=0.003) and FBG (p=0.01) increased significantly while prolactin level decreased significantly (p=0.02) in participants exposed to combined heat sources compared to others, indicating a significant correlation between sources of heat and the hormones and FBG. The length of occupation as a kitchen staff also had a significant association with the oestrogen level (0.003). The drastic increase in FSH and progesterone levels, along with the tremendous decrease in oestrogen and FBG, indicates a potential threat to fertility in female kitchen staff. Keywords: Heat, female kitchen staff, reproductive hormones.
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    Selected Liver Function Indices in Male Farmers Exposed to Pesticides
    (Al-Hikmah Journal of Health Sciences (AJOHS), 2023-06) Abubakar Zubair Lawal; Munirudeen Ibrahim; Zainab Ndache Mohammed; Kolawole Ayobami Ogunwale; Wasiu Olanrewaju Garuba; Abdulgafar Niyi Popoola; Godwin Olawoyin Adunmo; Ibrahim Eleha Suleiman; Akeem Olayinka Busari; Musbau Olusesan Balogun; Elizabeth Ibironke; Christiana Adekunle; Michael Adedotun; Abdulrazak Nuhu
    ABSTRACT Introduction: Exposure to environmental toxins and ensuing liver health outcomes has attracted global attention. This study was aimed at assessing the liver function indices among farmers exposed to pesticides. Methodology: This research was carried out on 130 apparently healthy male participants aged 18 years and above. The participants were randomly selected for this comparative cross-sectional study. The participants were further divided into two groups; the Pesticide-exposed group and the control group (non-exposed). Demographic characteristics of the participants were obtained by standard methods. Five milliliters of fasting blood samples were collected from each participant after an overnight fast (8 to 12 hours). A portion of the blood sample was dispensed into plain tubes for the estimation of serum Aspartate aminotransferase, alanine aminotransferase, albumin, and total protein. Statistical Package for Social Science (SPSS) 25.0 software was used for statistical analysis. Results: The results from this study suggest that exposure to pesticides may have adverse effects on the liver as evidenced in the observed significant (p ≥ 0.05) increase in serum AST, ALT, and decreased Albumin and Total protein values in the pesticide-exposed group when compared with the normal control.