Browsing by Author "Sunday Awe"
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- ItemDISTRIBUTION OF Plasmodium falciparum Chloroquine RESISTANCE TRANSPORTER (Pfcrt) AND Plasmodium falciparum MULTIDRUG RESISTANCE 1(Pfmdr-1) GENES IN ILORIN NORTH-CENTRAL NIGERIA(FUDMA Journal of Sciences (FJS), 2024-10) Abdulraheem Jimoh O; Oluwasogo Olalubi; Sunday AweGlobally, malaria is a peculiar health challenge particularly in continent of Africa. The ease of developing resistance to anti-malaria drugs by Plasmodium falciparum is a serious impediment towards programs aim at control and elimination of malaria. Consequently, drug efficacy surveillance is desirable to institute adequate and effective treatment policies. In this study, distribution of these genes in Plasmodium falciparum isolates in Ilorin metropolis were investigated. One hundred and three samples collected randomly from 5 hospitals in Ilorin metropolis. The samples were amplified at codon 76 and 86 for Pfcrt and Pfmdr-1 respectively using PCR / Restricted Fragment Length Polymorphism (RFLP). The most prevalent alleles were drug susceptible alleles in the study area (K76 and N86) with 31% and 40% respectively, while drug resistance alleles (86Y) have 13% and the least prevalence 2% was the mixed alleles K76T. UITH has the highest number of susceptible alleles followed by CSC 38% and 46% for K76 and N86 respectively. There are significant differences in the distribution of these alleles and the study sites (P< 0.05). The prevalence of resistance alleles in the area is a welcome development that can be employed for possibility of re-introduction of CQ for the treatment of malaria in the study area which will serve as an advantage over expensive ACT due to fact that it is safe cheap and readily affordable
- ItemFROM THE FIELD TO THE BOTTLES: WORKS OF THE INVISIBLE CREATURES(KWASU Press and Publishing, 2023-05) Sunday AweI give glory, praise and adoration to the Almighty God, the giver of live for the grace and journey so far, and for making me reach this position in my career. I count it a divine privilege and honour to stand before you to deliver the 11th Inaugural lecture of Kwara State University. I am highly delighted to present the story of my research activities over the years to this distinguished audience of town and gown. 2 An Inaugural lecture provides a golden opportunity for a newly/freshly appointed Professor to give an account of his contribution to the pool of knowledge in his area of specialization. This is the first inaugural lecture to be delivered in the Department of Microbiology and second from the Faculty of Pure and Applied Sciences of this great University. Mr. Ag. Vice Chancellor Sir, I had wanted to study Medicine at the University of Jos in 1988 but was not admitted as a result of federal government policy on admission into its universities. By providence I was offered admission to study B. Sc. Microbiology at University of Ilorin the following year, which I accepted through the wise counsel of my Biology teacher, Mr. Samuel Folorunsho Adebiyi, then of Ilesha Grammar School Ilesha, Osun State. After my first degree, I had a stint in the industry; working as a Quality Control Microbiologist at Unique Pharmaceuticals Nigeria Plc., Sango Ota, from 1996 to 2000. I left the Industry for University of Ilorin to pursue my M. Sc. degree programme in Microbiology between 2000 and 2002. Shortly after completion of my M. Sc. Programme, I was offered appointment as a Part time lecturer under the Science Laboratory Technology Training Programme at the University of Ilorin, and Department of Biology, Kwara State Polytechnic, Ilorin for a period of four years. Thereafter, I joined Joseph Ayo Babalola University, Ikeji Arakeji as one of the foundation staff in 2006, where I lectured for a year before moving to Ajayi Crowther University, Oyo due its proximity to University of Ilorin to enable me complete my PhD programme on time. On completion of my PhD programme in 2009, I was invited to join in the development of Salem University, Lokoja in 2010 where by the grace of God, I rose to the position of a Reader before joining the Department of Microbiology here in KWASU in January 2016, again to help in the development of the Postgraduate programme of the Department and by the grace of God, I was promoted Professor of 3 Microbiology in 2021, which was back dated to 2019 during the tenure of the late Vice Chancellor Professor Muhammed Mustapha Akanbi, SAN. May his soul rest in peace. Mr. Ag. Vice Chancellor Sir, this lecture is coming two years after my promotion to the post of a Professor of Microbiology of this great University. I feel highly honoured and elated today to stand before you and pay my dues by presenting this lecture, which I have titled “From the field to the bottles: Works of the Invisible Creatures”.
- ItemImpact of Malaria Parasiteamia and Haematologic parameters in Ilorin metropolis, North central Nigeria(World Journal of Advanced Research and Reviews, 2025-02-25) Jimoh Abdulraheem Olayemi; Oluwasogo Olalubi; Sunday AweBackground: Malaria is main cause of cause of Anaemia and thrombocytopenia and those with platelet counts less than 150,000/µL have a 12–15 times higher risk of contracting malaria than those with counts greater than 150,000/µL. Methodology: A prospective crossectional study was employed in this study. 331 patients at the University of Ilorin Teaching Hospital, Kwara State University Teaching Hospital, Sobi Specialist Hospital, Okelele Comprehensive Health Centre and Civil service Clinics in Ilorin Metropolis with age range 1-60 years who presented with malaria were recruited. While those on antimalaria drugs, those with cases of complicated malaria, pregnant women and those that refused consent were excluded from the study. Ethical clearances were obtained from both the state Ministry of Health (MOH/KS/EU/777/493) and The University of Ilorin Teaching Hospital Ilorin, (UITH PAN/2022/12/0223). The study followed ethical code of conduct 2019 (Helsinki). Blood samples were collected from all the participants, both thick and thin blood films were made, stained with diluted Giemsa 1:10 and these were then confirmed by Polymerase Chain Reaction (PCR). Blood counts were carried out using the Haematology Analyzer BC-5200 following manufacturer instructions, Results: Out of 331 patients screened, 103 (31.6%) were positive for parasitaemia and parasites density of >120000 was detected in 8 participants, P. falciparum was the only species detected. The mean values of Hb, Hct, platelet, WBC, lymphocytes and RBC were significantly low in malaria patients compared to non-infected controls and the difference is statistically significant.
- ItemImpact of Malaria Parasiteamia and Haematologic parameters in Ilorin metropolis, North central Nigeria(World Journal of Advanced Research and Reviews, 2025-02-25) Jimoh Abdulraheem Olayemi; Oluwasogo Olalubi; Sunday AweBackground: Malaria is the main cause of anaemia and thrombocytopenia, and those with platelet counts less than 150,000/µL have a 12–15 times higher risk of contracting malaria than those with counts greater than 150,000/µL. Methodology: A prospective cross-sectional study was employed in this study. 331 patients at the University of Ilorin Teaching Hospital, Kwara State University Teaching Hospital, Sobi Specialist Hospital, Okelele Comprehensive Health Centre and Civil service Clinics in Ilorin Metropolis with age range 1-60 years who presented with malaria were recruited. In comparison, those on antimalaria drugs, those with cases of complicated malaria, pregnant women and those who refused consent were excluded from the study. Ethical clearances were obtained from both the state Ministry of Health (MOH/KS/EU/777/493) and The University of Ilorin Teaching Hospital Ilorin, (UITH PAN/2022/12/0223). The study followed an ethical code of conduct in 2019 (Helsinki). Blood samples were collected from all the participants, both thick and thin blood films were made, and stained with diluted Giemsa 1:10 and these were then confirmed by Polymerase Chain Reaction (PCR). Blood counts were carried out using the Haematology Analyzer BC-5200 following manufacturer instructions, Results: Out of 331 patients screened, 103 (31.6%) were positive for parasitaemia and parasite density of >120000 was detected in 8 participants, P. falciparum was the only species detected. The mean values of Hb, Hct, platelet, WBC, lymphocytes and RBC were significantly low in malaria patients compared to non-infected controls and the difference is statistically significant.