Browsing by Author "Suleiman ZA"

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    A comparative study of Plasma Vitamin C levels in pre- eclamptic and normotensive pregnancies at the Lagos University Teaching Hospital
    (2015) Odeigah CC; Odeigah L; Olagunju FA; Suleiman ZA; Issa YF; Adesina KT; Saidu R; Raji HA; Ayeni MO; Jimoh AAG
    Background: Pre-eclampsia remains a major cause of maternal and perinatal morbidity and mortality in our environment. Research into methods of prevention of this disorder has been hampered by a poor understanding of the pathological mechanisms leading to pre-eclampsia. Recent studies suggest that oxidative stress (with reduced antioxidant defences) could lead to free radical mediated endothelial dysfunction in pre-eclampsia. Objectives: To determine the plasma vitamin C levels in pre-eclamptic and normotensive pregnant patients at LUTH, and to compare the levels of plasma vitamin C in both groups of patients with a view to investigate the association between plasma vitamin C level and preeclampsia. Method: A comparative study of plasma vitamin C levels in pre-eclamptic and normotensive pregnancies. Informed consent was obtained from 90 women admitted to the labour ward with singleton pregnancies between 28 and 40 weeks, who were divided into two groups: 30 preeclamptic patients and 60 normotensive patients (each pre-eclamptic patient was matched for parity with 2 normotensive patients). Venous blood was obtained from all the participants. Plasma vitamin C level was measured using High Performance Liquid Chromatography (HPLC). Data was analyzed using inferential statistical methods. Results: The results showed that mean plasma vitamin C level in the pre-eclamptic women was 119.3 ± 23.7 μg/ml, while the mean plasma vitamin C level in the normotensive pregnant patients was 246.5 ± 45.0 μg/ml. The mean concentration of plasma vitamin C level was significantly lower in the pre-eclamptic patients than in the normotensive patients (t=14.5; p<0.001) Conclusion: The study showed that pre-eclampsia is associated with decreased concentration of plasma vitamin C. There is the need for a local study to investigate the effect of vitamin C supplementation on pre-eclampsia.
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    Adherence to Antiretroviral therapy among Human Immunodeficiency Virus infected patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria.
    (2015) Olagunju FA; Odeigah LO; Suleiman ZA; Issa YF; Akanbi II A; Raji HA; Adesina KT; Saidu R; Ayeni OM; Jimoh AAG
    Background: When people living with HIV/AIDS (PLHAs) are able to meet its challenging adherence requirements, highly active antiretroviral therapy (HAART) can be a nearly miraculous drug regimen that drastically reduces viral replication and damage to the immune system, restores daily functioning and well being. Objectives: The study sought to determine the rate and sociodemographic factors affecting adherence to antiretroviral therapy. Also to find associations between adherence and some clinical parameters among HIV infected patients attending lentiviral clinic at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Methods: The study was a descriptive cross-sectional survey of a randomly selected 250 HIV infected adult patients who were on antiretroviral therapy for a minimum of three months under the Federal Government of Nigeria’s free drugs programme. Self-reported adherence and other data were collected using an interviewer-administered questionnaire. Results: Adherence rate to antiretroviral therapy among HIV-infected patients was 90%. Knowledge of respondents about adherence and the increase in CD4 counts were significantly associated with adherence level. An assessment of the relationship between rate of adherence and socio-demographic factors revealed that there were no statistically significant associations. Conclusion: The high rate of adherence was largely attributed to free drugs provided by the clinic, free CD4 counts and other investigations, regular health talk and adherence counseling provided by a high level man-power.