Browsing by Author "Saidu R"

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    A comparative study of Plasma Vitamin C levels in pre- eclamptic and normotensive pregnancies at the Lagos University Teaching Hospital
    (2015) Odeigah CC; Odeigah L; Olagunju FA; Suleiman ZA; Issa YF; Adesina KT; Saidu R; Raji HA; Ayeni MO; Jimoh AAG
    Background: Pre-eclampsia remains a major cause of maternal and perinatal morbidity and mortality in our environment. Research into methods of prevention of this disorder has been hampered by a poor understanding of the pathological mechanisms leading to pre-eclampsia. Recent studies suggest that oxidative stress (with reduced antioxidant defences) could lead to free radical mediated endothelial dysfunction in pre-eclampsia. Objectives: To determine the plasma vitamin C levels in pre-eclamptic and normotensive pregnant patients at LUTH, and to compare the levels of plasma vitamin C in both groups of patients with a view to investigate the association between plasma vitamin C level and preeclampsia. Method: A comparative study of plasma vitamin C levels in pre-eclamptic and normotensive pregnancies. Informed consent was obtained from 90 women admitted to the labour ward with singleton pregnancies between 28 and 40 weeks, who were divided into two groups: 30 preeclamptic patients and 60 normotensive patients (each pre-eclamptic patient was matched for parity with 2 normotensive patients). Venous blood was obtained from all the participants. Plasma vitamin C level was measured using High Performance Liquid Chromatography (HPLC). Data was analyzed using inferential statistical methods. Results: The results showed that mean plasma vitamin C level in the pre-eclamptic women was 119.3 ± 23.7 μg/ml, while the mean plasma vitamin C level in the normotensive pregnant patients was 246.5 ± 45.0 μg/ml. The mean concentration of plasma vitamin C level was significantly lower in the pre-eclamptic patients than in the normotensive patients (t=14.5; p<0.001) Conclusion: The study showed that pre-eclampsia is associated with decreased concentration of plasma vitamin C. There is the need for a local study to investigate the effect of vitamin C supplementation on pre-eclampsia.
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    Adherence to Antiretroviral therapy among Human Immunodeficiency Virus infected patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria.
    (2015) Olagunju FA; Odeigah LO; Suleiman ZA; Issa YF; Akanbi II A; Raji HA; Adesina KT; Saidu R; Ayeni OM; Jimoh AAG
    Background: When people living with HIV/AIDS (PLHAs) are able to meet its challenging adherence requirements, highly active antiretroviral therapy (HAART) can be a nearly miraculous drug regimen that drastically reduces viral replication and damage to the immune system, restores daily functioning and well being. Objectives: The study sought to determine the rate and sociodemographic factors affecting adherence to antiretroviral therapy. Also to find associations between adherence and some clinical parameters among HIV infected patients attending lentiviral clinic at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Methods: The study was a descriptive cross-sectional survey of a randomly selected 250 HIV infected adult patients who were on antiretroviral therapy for a minimum of three months under the Federal Government of Nigeria’s free drugs programme. Self-reported adherence and other data were collected using an interviewer-administered questionnaire. Results: Adherence rate to antiretroviral therapy among HIV-infected patients was 90%. Knowledge of respondents about adherence and the increase in CD4 counts were significantly associated with adherence level. An assessment of the relationship between rate of adherence and socio-demographic factors revealed that there were no statistically significant associations. Conclusion: The high rate of adherence was largely attributed to free drugs provided by the clinic, free CD4 counts and other investigations, regular health talk and adherence counseling provided by a high level man-power.
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    Exclusive breastfeeding as a predictor of a natural birth control method among women in the South West, Nigeria.
    (2014) Olaitan LO; Stephen JA; Odeigah LO; Saidu R; Issa YF; Adesina KT; Olarinoye OO; Raji KA; Jimoh AAG
    This study was carried out to assess the utilization of exclusive breastfeeding as a predicator of natural birth control among women in the south western Nigeria. Related literature was reviewed on different methods of National birth control with much emphasis on the useful ideas and the benefits of breastfeeding to both the nursing mothers and their babies. The population for the study consist only nursing mothers who are attending the infants welfare clinic, family planning clinic and ante-natal clinic which include civil servants, Traders and artisans. Four hundred subjects were randomly selected from about five thousands population of nursing mothers within the state in the south western Nigeria for the study. The instrument used for the study was self structured questionnaire that were validated by experts in the area of study and tested for the reliability of study using split half. A spearman rank order was used to analyze the result. A correlation coefficient of (0.75r) was obtained which ascertain its reliability for the study. The instrument was administered by the researcher and five research assistance. An inferential statistics of chi-square was used to analyze the formulated hypotheses. The result revealed that most respondents lack the knowledge about the benefit of exclusive breastfeeding, the nature of their work does not permit them to give exclusive breastfeeding. The health status of mothers and settlement pattern have influence on their compliance to exclusive breastfeeding. It is therefore recommended that appropriate steps through advocacy and campaign jingles be carried out by the stakeholders in the health sector; waiver should be given to nursing mothers to attend to their babies wherever the need arises to breastfeed them either at home or in the work place by their employers.