Browsing by Author "Rasheed Bolaji Ibrahim"

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    Antidiarrhoeal Activities of Ethanolic Extract of Aristolochia ringens Stem Bark in Castor Oil-Induced Diarrhoeal Albino Rats
    (2018) Rasheed Bolaji Ibrahim; Abdulhakeem Olanrewaju Sulyman; Fisayo Abraham Bamisaye; Lateefah Badrudeen Yusuf
    The antidiarrhoeal potentials of ethanolic extract of Aristolochia ringens stem back was evaluated in castor oil-induced diarrhoeal rats. The A. ringens stem back ethanolic extract was, in addition, screened for its phytoconstituents. Thirty albino rats of 150-180 g were randomized into six groups of five animals each for each of the three experiments and all administration were oral. Rats in groups I and II were administered 1.0 ml distilled water and 1% DMSO (Vehicle) respectively, while those in group III were administered 2.5 mg/kg b.wt loperamide hydrochloride as reference drug. Rats in groups IV, V and VI were administered 25, 50, and 100 mg/kg b.wt. ethanolic extract of A. ringens stem bark. The castor oil-induced diarrhoeal model was used, the weight and volume of the intestinal content was determined by enteropooling method and the intestinal motility was determined using activated charcoal method. The small intestine of the rats was also assessed for histopathological changes. The extract significantly and dose-dependently reduced the number of diarrhoeal faeces, the volume of intestinal accumulation and the distance moved by the fed charcoal in treated rats compared to the untreated diarrhoeal group (group II). The percentage inhibitions exhibited by the extract at 50 and 100 mg/kg body weight were significantly higher than that of the reference drug. Furthermore, the photomicrograph of the intestine of the extract treated rats showed intact intestinal architecture. Hence, ethanolic extract of Aristolochia ringens stem bark may contain phytochemicals with better antidiarrhoeal potentials which can be explored in the development of more viable antidiarrhoeal agents.
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    Effect of chitosan-silver nanoparticle composite-treated water on selected biochemical parameters of rats
    (Pharmacotherapy Group, University of Benin, Benin City, Nigeria., 2025) Raliat Abimbola Aladodo; Abdulhakeem Olarewaju Sulyman; Mutiu Adewunmi Alabi; Rasheed Bolaji Ibrahim; Juwon Samuel Afolayan; Ibrahim Opeyemi Ibrahim; Fausat Abimbola Jimoh; Yusuf Ayodeji Iyanda; Saheed Sabiu; Chidolue Chinenye Kingsley
    Purpose: To investigate the impact of chitosan-silver nanoparticles (chitosan-AgNP) composite-treated water on some biochemical parameters in the albino rats. Methods: Water samples were pretreated with chitosan-coated silver nanoparticles (chitosan-AgNPs) prior to oral administration in a rodent model. Following a 28-day experimental period, serum biochemical markers associated with hepatic and renal functions and enzymatic activities were quantitatively assessed to evaluate potential physiological and metabolic alterations. Results: Biochemical analysis revealed significant alterations in liver and kidney function markers in rats exposed to contaminated water. Liver alkaline phosphatase (ALP), aspartate aminotransferase (AST), and γ-glytamyl transferase (GGT) activities were significantly decreased (p < 0.05), while serum ALP, AST and GGT levels were significantly elevated (p < 0.05) in the contaminated water group compared to control. Serum urea and creatinine levels were significantly higher in rats exposed to contaminated water (90 ± 0.08 mg/dL and 21.73 ± 4.03 mg/dL, respectively) compared to the control group (43 ± 0.13 mg/dL and 16.37 ± 1.97 mg/dL, respectively; p < 0.05). Conversely, administration of chitosan-AgNP-treated water significantly reduced these elevations, bringing the values closer to control levels. Bacteriological analysis showed a drastic reduction in total coliform and fecal counts from 1.44 × 10⁷ CFU/mL and 7.2 × 10⁶ CFU/mL, respectively, to 0 CFU/mL after 27 days of chitosan-AgNP treatment. Conclusion: The findings suggest that chitosan-AgNP treatment significantly reduces bacterial load in water and positively affects selected biochemical parameters of albino rats, indicating its potential as a water treatment option.
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    Microencapsulation of eucalyptol in polyethylene glycol and polycaprolactone using particles from gas-saturated solutions
    (2019) Jubril Olayinka Akolade; Mohammed Balogun; Andri Swanepoel; Rasheed Bolaji Ibrahim; Abdullahi Ahmed Yusuf; Philip Labuschagne

    Application of supercritical carbon dioxide as an alternative solvent for microformulation of the volatile unstable drug, eucalyptol in polymeric composites.