Browsing by Author "Osunniran, Wahab Adesina"

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    Comparison of Solid and Solvent - Based Syntheses, Characterization and Antioxidant Property of Metal Complexes of Sodium Diclofenac
    (College of Natural and Applied Sciences, Fountain University, 2020) Bale, Adebayo Tajudeen; Osunniran, Wahab Adesina; Ayipo, Yusuf Oloruntoyin; Adeyemo, M.A; Obaleye, Joshua Ayoola
    Mechanosynthesis and solvent – based syntheses of transition metals (Ni, Co and Zn) complexes of Sodium diclofenac has been carried out by 1:1 molar ratio of the ligand to metal salts respectively. The synthesis of the metal complexes were confirmed by melting point determination, FT-IR (Fourier Transform Infra-red) and UV-visible spectroscopies. The ligand showed bidentate coordination to the metal ions through carboxylate moiety. Octahedral geometry was proposed for all the metal complexes. The antioxidant property of metal complexes was determined using DPPH (1,1-diphenyl-2-picrylhydrazyl) assay with Ascorbic acid as control. The antioxidant evaluation results revealed that the synthesized metal complexes are promising antioxidant agents.
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    Heteroleptic Transition Metal Complexes of Eflornithine Hydrochloride Monohydrate: Synthesis, Characterization, in silico and in vitro Biological Studies
    (Turkish Chemical Society, 2022-09-20) Bale, Adebayo Tajudeen; Osunniran, Wahab Adesina; Ayipo, Yusuf Oloruntoyin; Rajee, Abdullahi Ola; Bamigboye, Mercy Oluwaseyi; Obaleye, Joshua Ayoola
    Incessant development of resistance to drugs by microorganisms remains a major setback associated with the currently available antibiotics, thereby making imperative a continuous search for alternative candidates with improved efficacy. Previous studies have shown enhanced antimicrobial activity of some bioactive molecules upon coordination with metal ions. Thus, in this study, Cu(II), Co(II), and Ni(II) complexes of eflornithine hydrochloride monohydrate (EHM) were synthesized and probed for bactericidal activity via in vitro and in silico. The characterization results such as CHN analysis, FTIR, UV-visible magnetic susceptibility and Electrospray Ionization Mass Spectrometry (ESI-MS) reveal that EHM coordinates as a bidentate ligand to each central metal ion in the molar ratio 1:2 through O and N in the COO- and NH2 group respectively, and also suggest octahedral geometry in each complex. The physicochemical and pharmacokinetics parameters predicted in silico support the bio-applicability and safety of the complexes. From the in vitro antibacterial study, the complexes demonstrate improved activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa with an average minimum inhibitory concentration (MIC) of 0.01 mg/L similar to ciprofloxacin, compared to EHM whose MIC >1.00 mg/L. Although, not all the complexes satisfy Lipinski’s drugability rule of 5 due to their molecular weight, however, coordination with metal ions improves the biological activities of EHM and the complexes demonstrate potential for further transformation into antibiotic therapeutics.
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    Synthesis, Characterization and α-Amylase Inhibition Study of Substituted Schiff Base and Its Metal Complexes
    (2023-12-31) Bale, Adebayo Tajudeen; Osunniran, Wahab Adesina; Ajiboye, Abdulfatai Temitope
    Mechanochemical synthesis is considered as a green and sustainable approach to chemical reactions since it requires little or no solvent, making the process more environmentally friendly by reducing waste and minimizing solvent related hazards. In this study, substituted Schiff base was synthesized from 2-aminophenol and 2- hydroxy-1-naphthaldeyde via mechanochemical synthesis method. The metal complexes were synthesized by reacting the ligand with metal(II) chlorides in ratio 2:1. The synthesized compounds were characterized by colour, melting point, molar conductivity, FT-IR, and UV-Vis spectroscopy. The ligand and its metal complexes were screened for α-amylase inhibitory activity. FT-IR results showed absorption bands in between the ranges 1628-1632 cm-1 and 1585-1597 cm-1 indicating the formation of azomethine C=N and aromatic C=C respectively. The metal complexes showed M-O absorption bands in between the range 519-579 cm-1 and M-N band in between the range 461-484 cm-1. The synthesized compounds displayed significant inhibitory activities (IC50: 2.00-8.43 mg/mL) against α-amylase comparable to the reference compound, acarbose (IC50: 9.12 mg/mL). These compounds can serve as viable templates in the formulation of new active antidiabetic drugs.
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    Synthesis, FT-IR Spectroscopic Studies and in vitro FRAP Assay of some Chalcone Derivatives and their Metal Complexes
    (ACADEMIC STAFF UNION OF UNIVERSITIES, 2022) Bale, Adebayo Tajudeen; Daramola, Kehinde Dele; Osunniran, Wahab Adesina
    A variety of substituted chalcones, namely, 3”-aminochalcone, 2”,4”-dichlorochalcone, 2”-methoxychalcone, 4”-methoxychalcone and 2”-hydroxychalcone have been synthesized by Claisen-Schmidt condensation and characterised by melting point and FT-IR spectroscopic technique. The tin(II), cadmium(II) and copper(II)) complexes of the 2”-hydroxychalcone (4E2HC) with the formula [M(L)2] were subsequently prepared. The 2”-hydroxychalcone and its metal complexes were evaluated for in vitro radical scavenging activity by carrying out ferric reducing antioxidant power (FRAP) assay. In almost all cases, the metal complexes exhibited higher activities than the ligand (chalcone). Notable activity (11.63 µM) was observed for the cadmium complex of the 4-ethoxy-2”-hydroxychalcone at 10 µg/mL. Limited structure–activity relationship (SAR) was established by considering the effect of different groups attached to the aryl rings and the metal centers on varying antioxidant activity. The enhanced activity may be due to the presence of electron-rich metals and electron-releasing ethoxy (-OC2H5) and hydroxy (–OH) groups. The confirmed bioactive compounds from this study can be used as effective template in medicinal chemistry for drug discovery.
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    TOXICOLOGICAL ASSESSMENT OF SYNTHESIZED AND CHARACTERIZED TRANSITION METAL(II) COMPLEXES OF EFLORNITHINE HYDROCHLORIDE HYDRATE ON ALBINO RATS
    (Chemical Society of Ethiopia, 2020-12-15) Bale, Adebayo Tajudeen; Osunniran, Wahab Adesina; Obaleye, Joshua Ayoola; Tella, Adedibu Clement; Ayipo, Yusuf Oloruntoyin; Rajee, Abdullahi Ola
    Transition metal complexes of Cu(II), Co(II) and Ni(II) with eflornithine hydrochloride hydrate (EFN), an antitrypanosomiasis drug, as ligand have been synthesized and characterized by melting point, elemental analysis, Fourier transform infrared (FTIR), electronic spectra, magnetic susceptibility and electrospray ionization mass spectrometry (ESI-MS). The FTIR spectral data suggested the coordination modes of the ligand to be bidentate, coordinated to the metal ions through its carboxylate oxygen atom and an amino nitrogen atom. From the microanalytical data, the stoichiometry of the metal complexes is 1:2 (metal to ligand). The electronic absorption and magnetic susceptibility studies generally suggested octahedral geometry for the metal complexes. Toxicological evaluation of the ligand (EFN) and complexes were carried out using albino rats. Twenty-five albino rats that were used for the experiment were randomly divided into five groups and animals in group 1 served as a control. All the animals were sacrificed twenty-four hours after completion of their doses. The results revealed a high level of toxicity of EFN than the synthesized metal complexes.