Browsing by Author "Mutiu A. Alabi, Rita M. Sunday, Temitope Olowokere, Fatai A. Kareem and Folake Osanaiye"

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    Effect of bitters on the body weight, lipid profile, catalase and lipid peroxidation in experimental animals
    (Journal of Mdical Sciences, 2013) Mutiu A. Alabi, Rita M. Sunday, Temitope Olowokere, Fatai A. Kareem and Folake Osanaiye
    This study was designed to investigate the potential effect of hitters on body Weight, lipid profile (total cholesterol, triglyceride, high density lipoprotein (HIDL)-cholesterol and low density lipoprotein (LDL)-cholesterol), catalase and lipid peroxidation in the plasma and heart tissue of Albino rats. Three brands of bitters (Yoyo, Swedish and Living bitters) were administered daily for thirty-two days through oral rout to age matched twenty eight Albino rats of both sexes. The rats were grouped into four with seven rats per group. The control group was administered normal saline, the treatment groups were administered with Yoyo, Swedish and Living hitters respectively (15 mL kg_‘). The animals were sacrificed after thirty-two days. There was a significant (p<0.05) decrease in body weight, a reduction in cardiac total cholesterol, lipid peroxidation, triglyceride and LDL-cholesterol levels and an increase in catalase activity. There was also a significant reduction in plasma total cholesterol and triglyceride levels but significant increase in plasma catalase activity. Hence, hitters could be recommended to be taken as digestive, as it may help to reduced the body weight, cardiac total cholesterol, triglyceride, LDL-cholesterol levels, lipid peroxidation level and increase catalase activity.