Browsing by Author "Lawal Abubakar Z."

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    Effect of Aqueous Extract of Ocimum gratissimum (Scent Leaf) on Renal Profile of Male Wistar Rats
    (Al-Hikmah Journal of Health Sciences (AJOHS), 2021-12) Busari Akeem Olayinka; Salau Fatimoh Abimbola; Bashir Shefiat; Bolaji Moshood; Balogun Morufu Eyitayo; Ibrahim Munirudeen; Garuba Wasiu Olanrewaju; Popoola Niyi Abdulgafar; Adunmo Godwin O.; Lawal Abubakar Z.; Ogunwale Kolawole Tajudeen; Adedokun Kamoru Ademola; Ogundiran Simeon Makinde; Ahmad Muhammad Bello; Mohammed Idris Yahaya; Akinola Franklin Folasele; Adeosun Oyebola Ganiyu
    Abstract Humans have given the leaves of Ocimum gratissimum (O. gratissimum) a great deal of attention due to their vast medical usefulness, culinary application, and pharmacological effects. As a result, the study evaluated the effect of O. gratissimum on renal profile of male Wistar rats. Ten healthy male Wistar rats were randomized into test and control groups comprising of 5 animals each. The test group received 400mg/Kg O. gratissimum leaf extract whereas the control group was fed with normal rat diet and water. The rats were euthanized through cervical dislocation at the end of the experiment and blood sample was collected through heart puncture for serum assessment renal profile while the kidney was excised for histological examination. The Results showed a non-significant at p>0.05 increase in serum electrolytes and urea while significant at p<0.05 decrease in the mean serum creatinine level was observed in the test group compared to the control group. Also, the histological examination of the kidney tissue revealed a mild lymphocytic infiltration in the test group compared to the control group. Conclusively, the study suggested a dose-dependent toxicological effect of O. gratissimum on renal profile.