Browsing by Author "Garba Wasiu Olanrewaju"

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    (2025), Volume 11, Issue 1 Niyi et al. 22 https://ejournals.epublishing.ekt.gr/index.php/HealthResJ RESEARCH ARTICLE EFFECTS OF SALBUTAMOL ADMINISTRATION ON THE MORPHOLOGY AND CYTOAR- CHITECTURE OF THE CEREBELLUM AND HIPPOCAMPUS OF ADULT WISTAR RATS
    (Health and Research Journal, 2025-01) Popoola AbdulGafar Niyi; Ibrahim Munirudeen; Ibiyeye Ruqayyah Yetunde; Faniyi Ayodeji Amos; Balogun Musbau Olusesan; Busari Akeem Olayinka; Garba Wasiu Olanrewaju; Ogunwale Kolawole Ayobami; Lawal Abubakar Zubair; Suleiman Ibrahim Eleha; Adunmo Godwin Olawoyin; Nuhu Abdulrazak
    Abstract Background: Salbutamol is the most preferred and widely used drug for treating bronchial asthma and bronchospasm. Its abuse has however been reported amongst users. Most of the side effects reports on salbutamol are clinical based such as headache, tremor, weakness etc. This study, therefore, investigated the sub-acute effect of oral salbutamol on the general morphology of the cerebellum and hippocampus of adult Wistar rats. Method and Material: Twenty adult Male Wistar rats (125 – 224g) were divided into four groups of five rats each. The control (distilled water); the 20mg/kg salbutamol, the 30mg/kg salbutamol, and the 40mg/kg salbutamol groups. Drugs were administered orally for 21 days. The body weight of each animal was monitored throughout the experiment. On day 22, animals were euthanized, brains excised, fixed in 10% buffered formal-saline, cerebelli and hippocampi were identified and processed with Haematoxylin and Eosin staining techniques. Data were analysed by ANOVA at p≤0.05 level of significance using SPSS and results presented as mean ± SEM Results: Results showed that the animals that received 30mg/kg and 40mg/kg salbutamol had significant weight loss. The cerebellum of the 40mg/kg group showed eroded granule cell layer. Hippocampus also revealed pyknotic cells in the pyramidal cell layers at 30mg/kg and 40mg/kg. Conclusions: This study showed that salbutamol at relatively higher doses caused significant weight loss; degeneration of cerebellum granule cells, which might affect motor coordination; and pyknosis of hippocampal pyramidal cells which may affect learning and memory. Keywords: Salbutamol, weight loss, brain, degeneration.
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    Evaluation of Serum Creatine Kinase and Lactate Dehydrogenase Activities in Hypertensive Patients Attending General Hospital Ilorin, Kwara State, Nigeria
    (2021-12) Busari Akeem Olayinka; Onamadi Temitope Ayobami; Ibrahim Munirudeen; Balogun Morufu Eyitayo; Garba Wasiu Olanrewaju; Ogunwale Kolawole Tajudeen; Adunmo Godwin O.; Ahmad Muhammed Bello; Mohammed Idris Yahaya; Nassar Sulaiman Adebayo; Akinola Franklin Folasele; Popoola Niyi Abdulgafar; Lawal Abubakar Zubair; Oyeniyi Maroof Gbadebo; Eleha Suleiman
    Abstract The main factor contributing to morbidity and mortality is hypertension. Although blood pressure is a complicated feature, studies have shown that the activity of adenosine triphosphate (ATP)-generating enzymes like creatine kinase (CK) and lactate dehydrogenase (LDH) is a major predictor of hypertension. As a result, this study evaluated the activities of CK and LDH activities in hypertensive patients attending the General Hospital Ilorin, Kwara State. One hundred and sixty-one (161) hypertensive patients and thirty-nine (39) normotensive subjects were recruited into a case-control study of 200 participants. Body mass index (BMI) was estimated from each participant's measured weight and height, while the blood pressure was determined from the measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) using conventional mercury sphygmomanometer. A 5 mls sample of blood was taken from each subject, and the extracted serum was analyzed using an enzymatic-kinetic method to quantify the CK and LDH activities. Results showed that hypertensive patients had significantly at p<0.05 higher serum CK and LDH activities in hypertensive compared to apparently healthy normotensives. Thus, this study observed significantly increase CK and LDH activities in hypertensive patients