Browsing by Author "Adunmo Godwin O."

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Effect of Aqueous Extract of Ocimum gratissimum (Scent Leaf) on Renal Profile of Male Wistar Rats
    (Al-Hikmah Journal of Health Sciences (AJOHS), 2021-12) Busari Akeem Olayinka; Salau Fatimoh Abimbola; Bashir Shefiat; Bolaji Moshood; Balogun Morufu Eyitayo; Ibrahim Munirudeen; Garuba Wasiu Olanrewaju; Popoola Niyi Abdulgafar; Adunmo Godwin O.; Lawal Abubakar Z.; Ogunwale Kolawole Tajudeen; Adedokun Kamoru Ademola; Ogundiran Simeon Makinde; Ahmad Muhammad Bello; Mohammed Idris Yahaya; Akinola Franklin Folasele; Adeosun Oyebola Ganiyu
    Abstract Humans have given the leaves of Ocimum gratissimum (O. gratissimum) a great deal of attention due to their vast medical usefulness, culinary application, and pharmacological effects. As a result, the study evaluated the effect of O. gratissimum on renal profile of male Wistar rats. Ten healthy male Wistar rats were randomized into test and control groups comprising of 5 animals each. The test group received 400mg/Kg O. gratissimum leaf extract whereas the control group was fed with normal rat diet and water. The rats were euthanized through cervical dislocation at the end of the experiment and blood sample was collected through heart puncture for serum assessment renal profile while the kidney was excised for histological examination. The Results showed a non-significant at p>0.05 increase in serum electrolytes and urea while significant at p<0.05 decrease in the mean serum creatinine level was observed in the test group compared to the control group. Also, the histological examination of the kidney tissue revealed a mild lymphocytic infiltration in the test group compared to the control group. Conclusively, the study suggested a dose-dependent toxicological effect of O. gratissimum on renal profile.
  • Thumbnail Image
    Item
    Evaluation of Serum Creatine Kinase and Lactate Dehydrogenase Activities in Hypertensive Patients Attending General Hospital Ilorin, Kwara State, Nigeria
    (2021-12) Busari Akeem Olayinka; Onamadi Temitope Ayobami; Ibrahim Munirudeen; Balogun Morufu Eyitayo; Garba Wasiu Olanrewaju; Ogunwale Kolawole Tajudeen; Adunmo Godwin O.; Ahmad Muhammed Bello; Mohammed Idris Yahaya; Nassar Sulaiman Adebayo; Akinola Franklin Folasele; Popoola Niyi Abdulgafar; Lawal Abubakar Zubair; Oyeniyi Maroof Gbadebo; Eleha Suleiman
    Abstract The main factor contributing to morbidity and mortality is hypertension. Although blood pressure is a complicated feature, studies have shown that the activity of adenosine triphosphate (ATP)-generating enzymes like creatine kinase (CK) and lactate dehydrogenase (LDH) is a major predictor of hypertension. As a result, this study evaluated the activities of CK and LDH activities in hypertensive patients attending the General Hospital Ilorin, Kwara State. One hundred and sixty-one (161) hypertensive patients and thirty-nine (39) normotensive subjects were recruited into a case-control study of 200 participants. Body mass index (BMI) was estimated from each participant's measured weight and height, while the blood pressure was determined from the measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) using conventional mercury sphygmomanometer. A 5 mls sample of blood was taken from each subject, and the extracted serum was analyzed using an enzymatic-kinetic method to quantify the CK and LDH activities. Results showed that hypertensive patients had significantly at p<0.05 higher serum CK and LDH activities in hypertensive compared to apparently healthy normotensives. Thus, this study observed significantly increase CK and LDH activities in hypertensive patients