Effect of A. precarorius Aqueous Seed Extract on the Histology of Kidney, Lungs and Intestines of Wistar Rats
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Date
2013
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Journal of Pharmacology and Toxicology
Abstract
This study was carried out to evaluate the potential detect of aqueous extract of Abrus precatorius (A. precatorius) seeds on the histology of kidneys, lungs and intestines of Wistar rats. Aqueous extract of A. precatorius seeds was administered For fourteen days through intraperitoneal route tip) to age matched Wistar rats. The rats were grouped into four with five rats per group. The control group was administered 3 mL kg 1 distilled water while the treatment groups were administered 0.05, 0.10 and 0.20 mg/kg of aqueous extract of A. precatorius seeds. The animals were sacrificed after fourteen days. The kidneys, lungs, small and large intestine were removed, weighed and preserved in 10% formalin solution and embedded in paraffin wax. Tissues from these organs were stained for assessment of tissue morphology. Pathological changes were observed in the tissues of the treatment groups while no change was observed in the control group. The median lethal dose (LD5a) was determined to he 0.35 mg/g (i.p). The results showed that intraperitonial administration of aqueous extract of A. precatorius seeds may cause slight changes to these organs and caution should be exhibited in its use in traditional medicine.
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Citation
28. Sunday, R.M, Ilesanmi, O.R., Alabi, M.A., Osanaiye, F.G., Olowokere, T. and Otunla, T.A. (2013). Effect of A. precarious Aqueous Seed Extract on the Histology of Kidney, Lungs and Intestines of Wister Rats. Journal of Pharmacology and Toxicology. 8(2): 67-72. Published by Science Alert, Dubai, UAE. Available online at https://scialert.net/fulltext/?doi=jpt.2013.67.72. Doi: 10.3923/jpt.2013.67.72.